NF-κB 詳細
Molecule Name
Nuclear factor NF-kappa-B complex
分子の別称
NF-κB, nuclear factor kappa-B
Drug Development Progress
治験薬の数39
市販薬剤の数12
研究＆開発段階Approved
ターゲットの別称
NF-kappa B
NF-κB 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| NF-kappa-B decoy oligonucleotide | MP-40; MP-41; MP-42; AMS-001; SI-3104; AMG-0101; AMG-0102; AMG-0103; S-414114 | Phase 3 Clinical | Anges Mg, Osaka University | Dermatitis, Atopic; Intervertebral Disc Degeneration | 詳細 |
| RGN-259 | RGN-457; RGN-352; RGN-259; RGN-137; Tβ4; TB4; GBT-101; GBT-201; Thymosin beta 4-16-38; TB4 16-38; Thymosin beta4; Thymosin B4; Fx peptide | Phase 3 Clinical | National Institutes Of Health | Diabetes Mellitus; Dry Eye Syndromes; Epidermolysis Bullosa; Epidermolysis Bullosa Dystrophica; Epidermolysis Bullosa, Junctional; Graft vs Host Disease; Keratitis; Myocardial Infarction; Myocardial Ischemia; Pressure Ulcer; Sjogren's Syndrome; ST Elevation Myocardial Infarction; Varicose Ulcer; Xerophthalmia | 詳細 |
| Dazdotuftide | TRS-01 | Phase 3 Clinical | Tarsius Pharma | Glaucoma; Ocular inflammation; Uveitis; Uveitis, Anterior | 詳細 |
| Hypochlorous Acid | PR-022; PR-013 | Phase 3 Clinical | Realm Therapeutics | Cataract; Conjunctivitis, Allergic; Coronavirus Disease 2019 (COVID-19); Dermatitis, Atopic; Endophthalmitis; Virus Diseases | 詳細 |
| ARINA-1 | ARINA-1 | Phase 3 Clinical | Renovion Inc, University Of North Carolina At Chapel Hill | Bronchiectasis; Bronchiolitis Obliterans; Rejection of lung transplantation | 詳細 |
| Bezisterim | HE-3286; NE-3107 | Phase 3 Clinical | Harbor Therapeutics Inc | Alzheimer Disease; Arthritis, Rheumatoid; Brain Injuries, Traumatic; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Insulin Resistance; Parkinson Disease; Post-Acute COVID-19 Syndrome | 詳細 |
| Dimethylaminomicheliolide Fumarate | ACT-001 | Phase 3 Clinical | Tianjin Accendatech Technology Co Ltd | Brain metastases; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Glioblastoma; Glioma; Melanoma; Neuromyelitis Optica; Optic Neuritis; Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| Nanocurcumin (Tehran University of Medical Sciences) | Phase 2 Clinical | Tehran University Of Medical Sciences | Neoplasms; Periapical Diseases | 詳細 | |
| APPA | APPA; AKL-4; AKL-IV; APPA-1 | Phase 2 Clinical | AKL Research & Development Ltd | Osteoarthritis | 詳細 |
| CKBA | CKBA | Phase 2 Clinical | BCY Pharm Co Ltd | Plaque psoriasis; Rosacea; Vitiligo | 詳細 |
| IMR-261 | CXA-10; IMR-261; E-10-NO2-18:1 | Phase 2 Clinical | Complexa Inc | Acute Kidney Injury; Asthma; Glomerulosclerosis, Focal Segmental; Obesity; Phenylketonurias; Pulmonary Arterial Hypertension | 詳細 |
| Manganese butoxyethyl pyridyl porphyrin | BMX-001; MnTnBuOE-2-PyP5+ | Phase 2 Clinical | Duke University | Astrocytoma; Brain metastases; Carcinoma, Squamous Cell; Endometrial Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Ovarian Neoplasms; Rectal Neoplasms | 詳細 |
| CBL-0137 | CX-137; CBL-0137; CBLC-137; Curaxin-CBL0137 | Phase 2 Clinical | Cleveland Biolabs Inc | Central Nervous System Neoplasms; Diffuse Intrinsic Pontine Glioma; Diffuse midline glioma; Glioblastoma; Hematologic Neoplasms; Lymphoma; Neoplasms; Sarcoma; Skin Melanoma; Solid tumours | 詳細 |
| Zenuzolac | GIT-27; GIT-027; VGX-1027; GLS-1027 | Phase 2 Clinical | Geneone Life Science Inc | Coronavirus Disease 2019 (COVID-19); Pneumonia | 詳細 |
| Parthenolide | NSC-157035 | Phase 2 Clinical | Ashbury Biologicals | Alzheimer Disease; Cognition Disorders; Cognitive Dysfunction; Lymphoma | 詳細 |
| Withaferin A | Phase 2 Clinical | UofL Health | Ovarian Neoplasms | 詳細 | |
| TML-6 | TML-6 | Phase 2 Clinical | Merry Life Biomedical Co Ltd | Alzheimer Disease | 詳細 |
| Proximod | Phase 2 Clinical | Institue Of Materia Medica Chinese Academy Of Medical Science | Arthritis, Rheumatoid | 詳細 | |
| YIV-906 | PHY-906; KD-018 | Phase 2 Clinical | Phytoceutica Inc | Carcinoma, Hepatocellular; Colorectal Neoplasms; Diarrhea; Hepatitis B; Liver Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms | 詳細 |
| Ascorbic Acid/Menadione | Phase 2 Clinical | Ic-Medtech Co, Summa Health System | Joint Diseases; Prostatic Neoplasms | 詳細 | |
| LC-280126 | MIT-001; LC-280126; NecroX-7; LC28-0126 | Phase 2 Clinical | Lg Chemical Ltd | Hematologic Neoplasms; Lymphoma; Multiple Myeloma; Squamous Cell Carcinoma of Head and Neck; ST Elevation Myocardial Infarction; Stomatitis | 詳細 |
| Ginsenoside C-K | IH-901; LCHK-168; KBB-N1 | Phase 1 Clinical | Fudan University, Il-Hwa, Rohto, State Pharmaceutical Administration of Shanghai Institute of Pharmaceutical Industry, Zhejiang Hisun Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Multiple Myeloma | 詳細 |
| ORYN-1001 | ORTD-1; ORYN-1001 | Phase 1 Clinical | Oryn Therapeutics Llc | Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19) | 詳細 |
| CKD-712 | CKD-712 | Phase 1 Clinical | Chong Kun Dang Pharmaceutical Corp | Sepsis | 詳細 |
| LH-025 | LH-025 | Phase 1 Clinical | Dr August Wolff | Colitis, Ulcerative | 詳細 |
| Xempritolimod | KMRC-011; KMRC011; CNT-101; CNT-102 | Phase 1 Clinical | Korea Institute Of Industrial Technology | Acute Radiation Syndrome; Graft vs Host Disease; Neoplasms; Stomatitis | 詳細 |
| DEN-181 | DEN-181; CurcusomeRA; CurcusomeTMRA | Phase 1 Clinical | Dendright | Arthritis, Rheumatoid | 詳細 |
| ILB-202 | ILB-202; ILB202 | Phase 1 Clinical | Ilias Biologics Inc | Acute Kidney Injury; Intraoperative Complications | 詳細 |
| SFA-001 | SFA-001; SFA-001N | Phase 1 Clinical | SFA Therapeutics Inc, Temple University | Fibrosis; Metabolic Dysfunction-Associated Steatotic Liver Disease | 詳細 |
| Sprayable Hypochlorous Acid (RELIFE) | RLF-TD011 | Phase 1 Clinical | Relief Therapeutics Holding Sa | Epidermolysis Bullosa | 詳細 |
| Reformulated Cepharanthine (Sairiyo Therapeutics Inc) | PD-001; PD001 | Phase 1 Clinical | Sairiyo Therapeutics Inc | Communicable Diseases; Neoplasms | 詳細 |
| RHN-002 | RHN-002; RHN002 | Phase 1 Clinical | RH Nanopharmaceuticals LLC | Anemia, Sickle Cell; Pain, Postoperative | 詳細 |
| RHN-001 | RHN-001; RHN001 | Phase 1 Clinical | RH Nanopharmaceuticals LLC | 詳細 | |
| Hypochlorous Acid/Acetic Acid | SS0350; SS-0350 | Phase 1 Clinical | Softox Solutions As | Leg Ulcer; Varicose Ulcer | 詳細 |
| SHetA2 | Phase 1 Clinical | The University Of Oklahoma | Solid tumours | 詳細 | |
| TLZ-16-CL | TLZ-16-CL | Phase 1 Clinical | Beijing Taizhou Lize Pharmaceutical Technology Co Ltd | Cocaine-Related Disorders; Substance Withdrawal Syndrome | 詳細 |
| Misetionamide | GP-2250 | Phase 1 Clinical | Geistlich Pharma | Pancreatic Neoplasms | 詳細 |
| Anatabine citrate | RCP-006 | Clinical | Rock Creek, Roskamp Institute | Alzheimer Disease; Inflammation; Smoking Cessation; Thyroiditis, Autoimmune; Tobacco Use Disorder | 詳細 |
| Tarenflurbil spraygel (MIKA Pharma) | Clinical | Galen Ltd, Mika Pharma Gmbh | Arthritis, Rheumatoid; Dermatitis, Atopic; Inflammation; Pain; Skin Diseases | 詳細 |
市販薬剤に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | オリジナル製品名 | 最初に承認をした国 | 最初の適応症 | 最初に承認を受けた会社 | 承認された日付 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|---|---|---|---|---|
| Glucosamine Hydrochloride | Approved | Dona, Xicil, Dolenio, Dona 200-S, Viartril-S | Mainland China | Osteoarthritis | Bright Future Pharmaceutical Laboratories Ltd | 2004-03-17 | Chronic Periodontitis; Insulin Resistance; Obesity; Osteoarthritis | 詳細 | ||
| Charcoal | AST-120; MP-146 | Approved | Kureha Co | Kremezin, Zysa, Kremezin Fine Granules | Japan | Kidney Failure, Chronic | Mitsubishi Tanabe Pharma | 1991-10-04 | Asthma; Gastroesophageal Reflux; Hepatic Encephalopathy; Inflammatory Bowel Diseases; Intestinal Fistula; Irritable Bowel Syndrome; Kidney Failure, Chronic; Pouchitis; Renal Insufficiency, Chronic | 詳細 |
| Mepacrine hydrochloride | CBL-0102; CBLC-102; Curaxin CBLC-102 | Approved | Bayer AG | Atebrin, Maladin, Atabrine, Tenicridine | Lupus Erythematosus, Systemic; Giardiasis; Leishmaniasis; Malaria | Bayer AG | 1932-01-01 | Carcinoma, Renal Cell; Creutzfeldt-Jakob Syndrome; Giardiasis; Leishmaniasis; Lupus Erythematosus, Systemic; Malaria; Prostatic Neoplasms | 詳細 | |
| Anapsos | EQA-00 | Approved | Asac Pharmaceutical International | Psoriacen | Psoriasis; Dermatitis, Atopic | Asac Pharmaceutical International | 1972-01-01 | Dermatitis, Atopic; Psoriasis | 詳細 | |
| Metaxalone (Primus Pharmaceuticals) | Approved | Primus Pharmaceuticals Inc | United States | Muscle Spasticity | Primus Pharmaceuticals Inc | 2015-06-01 | Muscle Spasticity | 詳細 | ||
| Acetylaconitine | Approved | Mainland China | Pain | Shaanxi Xingbang Pharmacevtical Co Ltd | 1985-01-01 | Pain | 詳細 | |||
| Andrographolide/Sodium Hydrogen Sulfite | Approved | Bacterial Infections | 詳細 | |||||||
| Glucosamine Hydrochloride/Chondroitin sulfate | Approved | 詳細 | ||||||||
| Glucosamine Hydrochloride/Indomethacin | Approved | Mainland China | Spondylitis, Ankylosing; Spondylosis; Periarthritis; Arthritis, Rheumatoid; Arthritis | null | 1995-01-01 | Arthritis; Arthritis, Rheumatoid; Periarthritis; Spondylitis, Ankylosing; Spondylosis | 詳細 | |||
| Glucosamine Hydrochloride/Dermatan sulfate | Approved | 詳細 | ||||||||
| Iguratimod | T-614 | Approved | Jiangsu Simcere Pharmaceutical Co Ltd | 艾得辛, Colvet, Iremod, Kolbet, Careram | Mainland China | Arthritis, Rheumatoid | Hainan Simcere Pharmaceutical Co Ltd | 2011-08-15 | Arthritis, Rheumatoid; Graft vs Host Disease; Sjogren's Syndrome | 詳細 |
| Anvirzel | Approved | Nerium Biotechnology Inc, Ozelle Pharmaceuticals Inc | Anvirzel | Neoplasms | 詳細 |