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Melanotransferrin

Melanotransferrin信息

英文名称:Melanotransferrin上市药物数量0
中文名称黑素转铁蛋白临床药物数量2
靶点别称Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2最高研发阶段Phase 1 Clinical
英文名称:Melanotransferrin
中文名称黑素转铁蛋白
靶点别称Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2
上市药物数量0
临床药物数量2
最高研发阶段Phase 1 Clinical

Melanotransferrin产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (1)Cynomolgus (1)

  • 标签

    His Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

Melanotransferrin分子背景

Melanotransferrin (MTF), also known as CD228, P97, MELTF and MFI2, is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. MTF expression is low in normal tissues but high in tumor and embryonic tissues. In melanoma MTF is associated with tumor metastasis and angiogenesis and upregulated in lung cancer tissue and cell lines. In the brain MTF is expressed in capillary endothelium but also in the reactive microglia associated with senile plaques in Alzheimer's disease (AD).

Melanotransferrin分子别名

Melanotransferrin,CD228,MFI2,MAP97,MELTF
  • 分子信息
  • 产品列表