M-CSF R Overview
Molecule Name
Colony stimulating factor 1 receptor
Synonyms
CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Drug Development Progress
Drugs in Clinical Trials36
Approved Drugs11
Highest Development StageApproved
Target Synonym
CSFR，CD115 Antigen，FMS Proto-Oncogene，EC 2.7.10.1，CSF1R，Proto-Oncogene C-Fms，Macrophage Colony-Stimulating Factor 1 Receptor，FIM2，McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog，CSF-1R，C-FMS，Macrophage Colony Stimulating Factor I Receptor，CD115，HDLS，EC:2.7.10.1，EC 2.7.10，CSF-1-R，CSF-1 Receptor，FMS，BANDDOS，M-CSF-R，Colony Stimulating Factor 1 Receptor
Background
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
M-CSF R Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Simmitinib hydrochloride | SOMCL-15-290 | Phase 3 Clinical | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Breast Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gastroesophageal Junction Neoplasms; Neoplasms; Solid tumours; Stomach Neoplasms | Details |
| Seralutinib | PK-10571; GB-002 | Phase 3 Clinical | Gilead Sciences Inc | Pulmonary Arterial Hypertension | Details |
| Chiauranib | CS-2164; CS2164 | Phase 3 Clinical | Shenzhen Chipscreen Biosciences Co Ltd | Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Lymphoma, Non-Hodgkin; Neoplasms; Ovarian Neoplasms; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms | Details |
| Emactuzumab | RO-5509554; RG-7155; 6FY6EI1X8R | Phase 3 Clinical | F. Hoffmann-La Roche Ltd | Carcinoma; Carcinoma, Squamous Cell; Giant Cell Tumor of Tendon Sheath; Head and Neck Neoplasms; Lymphoma, Non-Hodgkin; Neoplasms; Prostatic Neoplasms; Solid tumours | Details |
| BS-001 | BS-001; BS001; oHSV-2; OH-2; OH2; OH2 injection; oHSV2hGM-CSF | Phase 3 Clinical | Wuhan Binhui Biotechnology Co Ltd | Bile Duct Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Colorectal Neoplasms; Digestive System Neoplasms; Esophageal Neoplasms; Glioblastoma; Head and Neck Neoplasms; Liver Diseases; Liver Neoplasms; Lung Neoplasms; Lymphoma; Melanoma; Neoplasms; Pancreatic Neoplasms; Sarcoma; Solid tumours; Urinary Bladder Neoplasms | Details |
| Simmitinib | SYHA-1817 | Phase 3 Clinical | CSPC Pharmaceutical Group Ltd | Biliary Tract Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Stomach Neoplasms | Details |
| OPN-7486 | PLX-7486; PLX7486-TsOH | Phase 2 Clinical | Plexxikon Inc | Giant Cell Tumor of Tendon Sheath; Neoplasms; Solid tumours | Details |
| Cabiralizumab | FPA-008; ONO-4687; BMS-986227 | Phase 2 Clinical | Five Prime Therapeutics Inc | Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Giant Cell Tumor of Tendon Sheath; Glioma; Head and Neck Neoplasms; Lymphoma, T-Cell, Peripheral; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms | Details |
| Narazaciclib | HX-301; ON-123300 | Phase 2 Clinical | Temple University | Breast Neoplasms; Endometrial Neoplasms; Glioblastoma; Glioma; Multiple Myeloma; Solid tumours | Details |
| Derazantinib | ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 | Phase 2 Clinical | Arqule Inc | Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Transitional Cell; Cholangiocarcinoma; Solid tumours; Stomach Neoplasms; Urogenital Neoplasms | Details |
| C-019199 | C019199 | Phase 2 Clinical | Fujian Haixi Pharmaceuticals Co Ltd | Breast Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Giant Cell Tumor of Tendon Sheath; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms | Details |
| Elzovantinib | TPX-0022 | Phase 2 Clinical | Turning Point Therapeutics Inc | Carcinoma, Non-Small-Cell Lung; Solid tumours; Stomach Neoplasms | Details |
| AMB-066 | AMB-066 | Phase 2 Clinical | AmMax Bio Inc | Colorectal Neoplasms | Details |
| Inhaled Nintedanib – dry powder (Avalyn Pharma) | AP02; AP 02 DP; AP-02; AP02-DP | Phase 2 Clinical | Avalyn Pharma Inc | Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Respiratory Tract Diseases | Details |
| BS-008 | BS001/BS006; BS001+BS006 | Phase 2 Clinical | Wuhan Binhui Biotechnology Co Ltd | Colorectal Neoplasms; Sarcoma; Solid tumours | Details |
| Enrupatinib | FB-1071; 4B71-01; EI-1071 | Phase 2 Clinical | Elixiron Immunotherapeutics Inc | Alzheimer Disease; Amyotrophic Lateral Sclerosis; Giant Cell Tumor of Tendon Sheath; Nervous System Diseases | Details |
| [11C]CPPC | Phase 2 Clinical | Johns Hopkins University | Amyotrophic Lateral Sclerosis; Post-Acute COVID-19 Syndrome | Details | |
| AMB-051 | AMB 053; AMB-055; AMG-820; AMB-051; AMB-05X | Phase 2 Clinical | Amgen Inc | Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Giant Cell Tumor of Tendon Sheath; Idiopathic Pulmonary Fibrosis; Neoplasms; Pancreatic Neoplasms; Solid tumours; Synovitis, Pigmented Villonodular; Testicular Neoplasms | Details |
| BC-006 | BC-006; BC006; ADG125; ADG-125 | Phase 2 Clinical | Adagene Inc | Giant Cell Tumor of Tendon Sheath; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Solid tumours | Details |
| Adrixetinib | Q-702 | Phase 2 Clinical | Lead Discovery Center GmbH, Max Planck Institute of Biochemistry, Vichem Chemie | Blastic Plasmacytoid Dendritic Cell Neoplasm; Carcinoma, Hepatocellular; Central Nervous System Lymphoma; Erdheim-Chester Disease; Esophageal Neoplasms; Graft vs Host Disease; Hematologic Neoplasms; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms; Neoplasms, Plasma Cell; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms; Waldenstrom Macroglobulinemia | Details |
| SYHA-1813 | SYHA1813 | Phase 2 Clinical | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Runshi Pharmaceutical Technology Co Ltd | Brain metastases; Carcinoma, Renal Cell; Colorectal Neoplasms; Giant Cell Tumor of Tendon Sheath; Glioma; Gliosarcoma; Liver Neoplasms; Lung Neoplasms; Meningioma; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Thyroid Neoplasms | Details |
| LY-3022855 | IMC-CS4; LY-3022855 | Phase 1 Clinical | Eli Lilly And Company | Melanoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Solid tumours | Details |
| PMI-04 | PMI-04 | Phase 1 Clinical | Precision Molecular Inc | Nerve Degeneration; Neuroinflammatory Diseases | Details |
| HH185 | 3D-185; 3-D185; HH-185; 3D185 | Phase 1 Clinical | ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Medicilon Inc | Solid tumours | Details |
| Edicotinib | PRV-6527; JNJ-244; JNJ-40346527-AAC-G-002; JNJ-40346527; JNJ-527 | Phase 1 Clinical | Johnson & Johnson | Alzheimer Disease; Arthritis, Rheumatoid; Cognitive Dysfunction; Crohn Disease; Hodgkin Disease; Leukemia, Myeloid, Acute; Prostatic Neoplasms | Details |
| Pamufetinib | TAS-115 | Phase 1 Clinical | Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd | Neoplasms | Details |
| JDB-383 | JDB-383 | Phase 1 Clinical | Shanghai Jiabao Yaoyin Pharmaceutical Technology Co Ltd | Giant Cell Tumor of Tendon Sheath | Details |
| HMPL-653 | HMPL-653 | Phase 1 Clinical | Giant Cell Tumor of Tendon Sheath; Solid tumours; Testicular Neoplasms | Details | |
| AK-150 (Akeso) | AK150; AK-150 | Phase 1 Clinical | Solid tumours | Details | |
| Nintedanib Esylate Inhalation Powder(Cspc) | Phase 1 Clinical | Cspc-Nbp Pharmaceutical Co Ltd | Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis | Details | |
| MNKD-201 | MNKD-201; MKND-201 | Phase 1 Clinical | MannKind Corp | Idiopathic Pulmonary Fibrosis | Details |
| ETH-155036 | ETH-155036; ETH155036 | Phase 1 Clinical | Shengke Pharmaceutical (Jiangsu) Co Ltd | Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | Details |
| ND-003 (NewDEL Biotech) | ND003 (NewDEL Biotech); ND-003 (NewDEL Biotech); ND003; JND-5932 | Phase 1 Clinical | Jinan University, Shenzhen NewDEL Biotech Co Ltd | Dermatitis, Atopic; Gastrointestinal Stromal Tumors; Idiopathic Pulmonary Fibrosis; Neoplasms; Pulmonary Fibrosis; Renal fibrosis; Renal Insufficiency, Chronic; Solid tumours | Details |
| Caflanone | FBL-03G | Phase 1 Clinical | Flavocure Biotech Inc | Pancreatic Neoplasms | Details |
| TT-00420/Atezolizumab | Phase 1 Clinical | TransThera Sciences (Nanjing) Inc | Gastrointestinal Neoplasms | Details | |
| AGX-0073 | AGX-0073 | Phase 1 Clinical | Shanghai Aojian Biological Technology Co Ltd | Solid tumours | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Vimseltinib | DCC-3014; DP-6865 | Approved | Deciphera Pharmaceuticals Llc | ROMVIMZA | United States | Giant Cell Tumor of Tendon Sheath | Deciphera Pharmaceuticals Inc, Deciphera Pharmaceuticals | 2025-02-14 | Giant Cell Tumor of Tendon Sheath; Graft vs Host Disease; Neoplasms; Synovitis, Pigmented Villonodular | Details |
| Regorafenib | DAST; BAY-73-4506 | Approved | Bayer AG | Stivarga, Resihance | United States | Colorectal Neoplasms | Bayer Healthcare Pharmaceuticals Inc | 2012-09-27 | Adenocarcinoma; Adenoma; Bile Duct Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastrinoma; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glucagonoma; Hemangiosarcoma; Insulinoma; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Meningioma; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma; Sarcoma, Ewing; Solid tumours; Somatostatinoma; Stomach Neoplasms; Thymoma; Thyroid Neoplasms | Details |
| Nintedanib Esylate | BIBF-1120 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Ofev, Vargatef | United States | Idiopathic Pulmonary Fibrosis | Boehringer Ingelheim International Gmbh | 2014-10-15 | Adenocarcinoma, Clear Cell; Appendiceal Neoplasms; Asbestosis; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Endometrial Stromal Tumors; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Mesothelioma; Multiple Myeloma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Fibrosis; Radiation Pneumonitis; Rejection of lung transplantation; Sarcoma; Scleroderma, Systemic; Silicosis; Small Cell Lung Carcinoma; Solid tumours; systemic sclerosis-associated interstitial lung disease; Telangiectasia, Hereditary Hemorrhagic; Uterine Neoplasms | Details |
| Pacritinib Citrate | ONX-0803; SB-1518 | Approved | S*BIO Pte Ltd | VONJO, Epjevy, ENPAXIQ | United States | Primary Myelofibrosis | Sobi | 2022-02-28 | Bone Marrow Diseases; Carcinoma, Non-Small-Cell Lung; Castleman Disease; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Coronavirus Infections; Graft vs Host Disease; Hematologic Diseases; Hepatic Insufficiency; Hodgkin Disease; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Lymphoma; Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Myelodysplastic Syndromes; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Sarcoma, Kaposi; Thrombocythemia, Essential; Thrombocytopenia; VEXAS Syndome; Waldenstrom Macroglobulinemia | Details |
| Pimicotinib | ABSK-021 | Approved | ABbisko Therapeutics Co Ltd | 贝捷迈 | Mainland China | Giant Cell Tumor of Tendon Sheath | Merck Serono (Beijing) Pharmaceutical Co Ltd | 2025-12-16 | Amyotrophic Lateral Sclerosis; Giant Cell Tumor of Tendon Sheath; Graft vs Host Disease; Lung Neoplasms; Neoplasms; Pancreatic Neoplasms; Sarcoma; Solid tumours; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms | Details |
| Surufatinib | HMPL-012 | Approved | 苏泰达, SULANDA | Mainland China | Neuroendocrine Tumors | Hutchison Medipharma Ltd | 2020-12-29 | Appendiceal Neoplasms; Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Neuroendocrine; Hematologic Neoplasms; Hepatic Insufficiency; Intestinal Neoplasms; Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Renal Insufficiency; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms | Details | |
| Sunitinib Malate | PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt | Approved | Pfizer Inc | Sutent, 索坦 | United States | Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell | Cppi Cv | 2006-01-26 | Abdominal Neoplasms; Adenocarcinoma; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenocortical Carcinoma; AIDS-Related Complex; Amyloidosis; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Barrett Esophagus; Brain metastases; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic; Carcinoma, Adenosquamous; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Choriocarcinoma; Chronic eosinophilic leukemia (CEL); Cognition Disorders; Colorectal Neoplasms; Diabetic macular oedema; Endodermal Sinus Tumor; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Fibrosarcoma; Gastrointestinal Stromal Tumors; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangi | Details |
| Axatilimab | SNDX-6352; UCB-6352; INCA-34176; INCA034176; INCA-034176 | Approved | Ucb | NIKTIMVO | United States | Graft vs Host Disease | Incyte Corp | 2024-08-14 | Bone Marrow Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Coronavirus Infections; Cytokine Release Syndrome; Graft vs Host Disease; Hodgkin Disease; Idiopathic Pulmonary Fibrosis; Leukemia, Myelogenous, Chronic; Leukemia, Myelomonocytic, Chronic; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms; Respiratory Distress Syndrome, Adult; Solid tumours; Triple Negative Breast Neoplasms | Details |
| Pexidartinib | PLX-3397 | Approved | Daiichi Sankyo Co Ltd | Turalio | United States | Giant Cell Tumor of Tendon Sheath | Daiichi Sankyo Inc | 2019-08-02 | Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumor of Tendon Sheath; Giant Cell Tumors; Glioblastoma; Hodgkin Disease; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Melanoma; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Neurofibroma, Plexiform; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular | Details |
| Mirimostim | P-100; CSF-HU | Approved | Jcr Pharmaceuticals Co Ltd | Costilate, Leukoprol | Japan | Neutropenia | Jcr Pharmaceuticals Co Ltd | 1991-01-01 | Neutropenia | Details |
| Pazopanib Hydrochloride | GSK-786034; GW-786034B; SB-786034; GW-786034 | Approved | Glaxosmithkline Plc, Novartis Pharma Ag | 维全特, Armala, Votrient, Patorma | United States | Carcinoma, Renal Cell; Sarcoma | Novartis Pharma Ag | 2009-10-19 | Adenocarcinoma, Follicular; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Chondrosarcoma; Chondrosarcoma, Extraskeletal Myxoid; Choriocarcinoma; Colorectal Neoplasms; Dermatofibrosarcoma; Endodermal Sinus Tumor; Epistaxis; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gastrinoma; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Glucagonoma; Hemangiosarcoma; Herpes Genitalis; Herpes Simplex; HIV Infections; Hormone-Resistant Prostate Neoplasms; Insulinoma; Leiomyosarcoma; Leukemia, Myeloid, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Macular Degeneration; Medullary thyroid cancer (MTC); Melanoma; Mesothelioma; Multiple Endocrine Neoplasia T | Details |