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Integrin alpha V beta 6

Integrin alpha V beta 6信息

英文名称:Integrin alpha-V/beta-6上市药物数量0
中文名称整合素α-V/β-6复合体临床药物数量6
靶点别称最高研发阶段Phase 3 Clinical
英文名称:Integrin alpha-V/beta-6
中文名称整合素α-V/β-6复合体
靶点别称
上市药物数量0
临床药物数量6
最高研发阶段Phase 3 Clinical

Integrin alpha V beta 6产品列表

  • 属性

    Protein (7)Cell (1)

  • 产品库

    在线 (8)

  • 物种

    Human (3)Mouse (2)Cynomolgus (1)Rat (1)Mouse & Human (1)

  • 标签

    His Tag (5)His Tag & Avi Tag (2)- (1)

  • 标记

    Unconjugated (5)Biotin-labeled (2) (1)

共 8 项数据
  • 1

Integrin alpha V beta 6分子背景

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

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