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IL-3 R alpha

IL-3 R alpha

IL-3 R alpha 詳細

Molecule Name
Interleukin-3 receptor subunit alpha
分子の別称
IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha
Drug Development Progress
治験薬の数40
市販薬剤の数1
研究＆開発段階Approved
ターゲットの別称
IL3RY，IL-3RA，CD123 Antigen，IL3RX，IL-3R Subunit Alpha，IL3R，IL-3 Receptor Subunit Alpha，IL-3 Receptor Alpha SP2 Isoform，Interleukin 3 Receptor Subunit Alpha，IL3RAY，IL-3R-Alpha，CD123，HIL-3Ra，IL3RA，Interleukin 3 Receptor， Alpha (Low Affinity)，Interleukin-3 Receptor Subunit Alpha，Interleukin-3 Receptor alpha Subunit
バックグランド
Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

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