IL-2 R beta 詳細
Molecule Name
Interleukin-2 receptor beta chain
分子の別称
IL2RB,RP5-1170K4.6,CD122,P70-75
Drug Development Progress
治験薬の数15
市販薬剤の数0
研究＆開発段階Phase 3 Clinical
ターゲットの別称
IL2RB，IMD63，IL-2RB，p75，CD122，Interleukin 2 Receptor Subunit Beta，Interleukin-15 Receptor Subunit Beta，Interleukin 15 Receptor， Beta，Interleukin 2 Receptor， Beta，IL-2R Subunit Beta，CD122 Antigen，P70-75，IL15RB，High Affinity IL-2 Receptor Beta Subunit，Interleukin-2 Receptor beta Subunit，Interleukin-2 receptor subunit beta，IL-2 receptor subunit beta，High affinity IL-2 receptor subunit beta
バックグランド
Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit.
CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
IL-2 R beta 製品リスト
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V***n2025-02-11I bought this Human recombinant IL-2 R β / CD122 protein to test some anti-CD122 antibodies using ELISA assays where I coat the plate with the CD122 protein. I observed the expected affinity (Kd) results for my antibody (0.3 µg/mL), and I also observed the same results whether I used the CD122 protein freshly reconstituted or freeze-thawed once, showing that this is a really robust purified protein! Lastly, I compared coating my ELISA plates with varying concentrations of CD122 protein (0.25 - 8 µg/mL), finding that I could coat my plates with very little proteins and still observed consistent affinity measurements. This product is a really robust! I will definitely be buying products from Acro Biosystems in the future.