IL-1RL1 詳細
Molecule Name
Interleukin-1 receptor-like 1
分子の別称
IL1RL1,DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1
Drug Development Progress
治験薬の数5
市販薬剤の数0
研究＆開発段階NDA/BLA
ターゲットの別称
ST2，IL1RL1，Protein ST2，DER4，T1，Interleukin 1 Receptor Like 1，Homolog Of Mouse Growth Stimulation-Expressed，Interleukin 1 Receptor-Related Protein，Growth Stimulation-Expressed，FIT-1，IL33R，ST2L，ST2V，Interleukin-1 Receptor-Like 1 Protein，EC:3.2.2.6，Interleukin-1 Receptor-Like 1
バックグランド
Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
IL-1RL1 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| Astegolimab | AMG-282; RG-6149; RO-7187807 | Phase 3 Clinical | Amgen Inc, F. Hoffmann-La Roche Ltd | Coronavirus Disease 2019 (COVID-19); Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive | 詳細 |
| AK-139 | AK139; AK-139 | Phase 2 Clinical | Kangfang Biotechnology (Cayman) Co Ltd | Asthma; Chronic rhinosinusitis with nasal polyps (CRSwNP); Chronic Urticaria; Dermatitis, Atopic; Hypersensitivity; Prurigo Nodularis; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal | 詳細 |
| TQC-2938 | TQC2938; TQC-2938 | Phase 2 Clinical | Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group | Asthma; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Seasonal | 詳細 |
| Recombinant humanized anti-ST2 monoclonal antibody | 9-MW1911; 9MW-1911; 9-MW-1911; 9MW1911 | Phase 2 Clinical | Mabwell (Shanghai) Bioscience Co Ltd | Asthma; Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive | 詳細 |
| NEROFE | Phase 1 Clinical | Immune System Key Ltd | Neoplasms; Solid tumours | 詳細 |