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Her2

Her2

Her2 詳細

Molecule Name
Receptor protein-tyrosine kinase erbB-2
分子の別称
ERBB2,CD340,HER-2,neu,HER2,MLN19,NEU,NGL,TKR1
Drug Development Progress
治験薬の数229
市販薬剤の数48
研究＆開発段階Approved
ターゲットの別称
EC 2.7.10.1，HER-2/Neu，Herstatin，HER-2，TKR1，Receptor， ErbB-2，V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2， Neuro/Glioblastoma Derived Oncogene Homolog，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2，Neuroblastoma/Glioblastoma Derived Oncogene Homolog，C-Erb B2/Neu Protein，CD340 Antigen，EC:2.7.10.1，EC 2.7.10，MLN 19，CD340，Tyrosine kinase-type cell surface receptor HER2，Receptor tyrosine-protein kinase erbB-2，ERBB2，MLN19，Proto-oncogene Neu，Erb-B2 Receptor Tyrosine Kinase 2，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2，Neuro/Glioblastoma Derived Oncogene Homolog，Human Epidermal Growth Factor Receptor 2，Metastatic Lymph Node Gene 19 Protein，Proto-Oncogene C-ErbB-2，P185erbB2，HER2，NGL，NEU，V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog)
バックグランド
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

Her2 製品リスト

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  • M***e2025-03-13
    Biotinylated Human Her2 / ErbB2 Protein, His,Avitag™, premium grade
    Great pricing and great products! Improvement would be to give open access to the technical information (e.g. protocols and reconstitution details).
  • G***z2025-03-12
    Human Her2 / ErbB2 Protein, His Tag (Mass Spec & MALS verified)
    We bought the Her2 to perform SPR to determine the binding affinity of in house produced herceptin. Using the His tag it was easy to capture the protein with amine coupled anti His antibody on the sensor chip surface. Therefore we could prove our antibody has full binding functionality very easily using the biacore T200 system. Ordering and shipping was really simple and all the necessary documentation can be found online. Although I didn't find the CoA in the first place everything was described easily and protocols of different analyses were available.
  • M***t2025-01-15
    Biotinylated Human Her2 / ErbB2 Protein, His,Avitag™, premium grade
    I used the biotinylated HER2 antigen from ACRO Biosystems for several applications, including phage panning, BLI, and phage ELISA, and it performed very well across all assays. The high purity and specific biotinylation allowed for reliable streptavidin binding, ensuring reproducible results. I have had very good luck with all Acro products during my career in science. Highly recommended for precision-driven workflows!