GUCY2D Overview
Molecule Name
Retinal guanylyl cyclase 1
Synonyms
GUCY2D,Retinal guanylyl cyclase 1,RETGC-1,CORD6,GUC1A4,GUC2D,ROS-GC
Drug Development Progress
Drugs in Clinical Trials1
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
RETGC-1，CG-E，Guanylate cyclase 2D， retinal，Rod outer segment membrane guanylate cyclase (ROS-GC)，CORD6，GUC1A4，GUC2D，RETGC，RETGC1
Background
GUCY2D also known as CORD6, GUC1A4, GUC2D ROS-GC and RETGC-1, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane.
GUCY2D Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| ATSN-101 | SAR-439483; ATSN-101 | Phase 2 Clinical | University Of Florida | Leber Congenital Amaurosis | Details |