GSK-3beta Overview
Molecule Name
Glycogen synthase kinase-3 beta
Synonyms
GSK3B,Glycogen synthase kinase-3 beta
Drug Development Progress
Drugs in Clinical Trials4
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
EC 2.7.11，EC:2.7.11.26，EC:2.7.11.1，Serine/threonine-protein kinase GSK3B，Glycogen synthase kinase-3 beta，GSK3B，Glycogen Synthase Kinase 3 Beta，GSK-3 Beta，GSK3beta Isoform，EC 2.7.11.26，EC 2.7.11.1
Background
Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of Alzheimer's disease (AD). GSK-3beta is involved in the formation of paired helical filament (PHF)-tau, which is an integral component of the neurofibrillary tangle (NFT) deposits that disrupt neuronal function, and a marker of neurodegeneration in AD.
GSK-3beta Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Tideglusib | NP-12; AMO-02; NP-031112 | Phase 3 Clinical | Noscira Sa | Alzheimer Disease; Amyotrophic Lateral Sclerosis; Autism Spectrum Disorder; Cardiomyopathies; Myotonic Dystrophy | Details |
| Ruboxistaurin Mesilate Hydrate | LY-333531; REC 3599; SM 030 | Phase 2 Clinical | Eli Lilly And Company | Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic macular oedema; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Gangliosidoses, GM2; Heart Failure; Hyperpigmentation; Melanosis | Details |
| Elraglusib | 9-ING-41 | Phase 2 Clinical | Actuate Therapeutics Inc, Northwest University, University Of Illinois At Chicago | Adenocarcinoma; Bone metastases; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Colorectal Neoplasms; Dermatofibrosarcoma; Diffuse Intrinsic Pontine Glioma; Glioma; Hemangiosarcoma; Kidney Neoplasms; Leiomyosarcoma; Leukemia-Lymphoma, Adult T-Cell; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Meningioma; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Osteosarcoma; Pancreatic Neoplasms; Primary Myelofibrosis; Rhabdomyosarcoma; Salivary Gland Neoplasms; Sarcoma; Sarcoma, Ewing; Sarcoma, Synovial | Details |
| Asnuciclib | CDKI-73; LS-007; QHRD-107 | Phase 2 Clinical | Shandong University, University Of South Australia | Leukemia, Myeloid, Acute | Details |