Growth Hormone R Overview
Molecule Name
Growth hormone receptor
Synonyms
GHR,GHBP,GH receptor
Drug Development Progress
Drugs in Clinical Trials31
Approved Drugs29
Highest Development StageApproved
Target Synonym
GHR，Somatotropin receptor，Serum-binding protein，GH-binding protein，GHBP，Growth Hormone Receptor，Growth Hormone Binding Protein，GH Receptor，Serum Binding Protein，GHIP，Receptors， Somatotropin
Background
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Growth Hormone R Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| PEGylated recombinant somatropin (Anhui Anke Biotechnology) | Phase 3 Clinical | Anhui Anke Biotechnology (Group) Co Ltd | Failure to Thrive; Growth hormone deficiency | Details | |
| Recombinant growth hormone-albumin fusion protein (Younuojin Biotech) | Phase 3 Clinical | Zhejiang Younuojin Biological Engineering Co Ltd | Growth Disorders; Growth hormone deficiency | Details | |
| Somatropin biosimilar (AryaTinaGene) | Phase 3 Clinical | Aryatinagene Biopharmaceuticals | Growth hormone deficiency | Details | |
| Growth Hormone and Platelet-Rich Plasma (Integrant) | Phase 3 Clinical | Integrant Pty Ltd | Osteoarthritis, Knee | Details | |
| Long-acting growth hormone (Kexing) | GB08; GB-08 | Phase 3 Clinical | Shenzhen Kexing Pharmaceutical Co Ltd | Growth hormone deficiency | Details |
| Recombinant human growth hormone (Genetics & Ivf Institute) | Phase 3 Clinical | Genetics & Ivf Institute | Growth hormone deficiency | Details | |
| Somatropin (Beni Suef University) | Phase 3 Clinical | Beni Suef University | Infertility; Primary Ovarian Insufficiency | Details | |
| AK-2017 | AK2017; AK-2017 | Phase 3 Clinical | Anhui Anke Biotechnology (Group) Co Ltd | Growth hormone deficiency; Idiopathic short stature | Details |
| Recombinant human growth hormone (Junhemeng Biopharmaceutical) | Phase 3 Clinical | Junhemeng Biopharmaceutical (Hangzhou) Co Ltd | Growth Disorders | Details | |
| Y-shape pegylated somatropin (Xiamen Amoytop Biotech ) | Phase 3 Clinical | Xiamen Amoytop Biotech Co Ltd | Growth hormone deficiency; Idiopathic short stature; Premature Birth; Turner Syndrome | Details | |
| Recombinant human growth hormone (Xiamen Amoytop Biotec) | Phase 2 Clinical | Xiamen Amoytop Biotech Co Ltd | Dwarfism; Growth hormone deficiency; Idiopathic short stature; Turner Syndrome | Details | |
| Cimdelirsen | ISIS-766720; ISIS-GHR-LRx; IONIS-GHR-LRx; IONIS-GHR-LRX | Phase 2 Clinical | Ionis Pharmaceuticals Inc | Acromegaly | Details |
| Vineurocin | NA-704 | Phase 2 Clinical | Neuroactiva Inc | Alzheimer Disease; Amyotrophic Lateral Sclerosis | Details |
| Atesidorsen | COR-004; ATL-1103 | Phase 2 Clinical | Ionis Pharmaceuticals Inc | Acromegaly | Details |
| ALXN-2420 | ALXN2420; ALXN-2420; AZP-3813 | Phase 2 Clinical | Alexion Pharmaceuticals Inc | Acromegaly | Details |
| Recombinant human growth hormone(Baylor College of Medicine) | Phase 2 Clinical | Baylor College Of Medicine | Growth hormone deficiency; Persian Gulf Syndrome | Details | |
| ALT-P1 | ALT-P1 | Phase 2 Clinical | Alteogen Inc | Growth hormone deficiency | Details |
| Somatropin (CJ HealthCare Corporation) | CJ-40002; hGH-NexP | Phase 2 Clinical | Alteogen Inc, HK inno.N Corporation | Growth hormone deficiency | Details |
| LAT-8881 | AOD-9604; LAT-8881 | Phase 1 Clinical | Metabolic Pharmaceuticals | Diabetic peripheral neuropathy; Migraine Disorders; Neuralgia; Neuralgia, Postherpetic; Radiculopathy | Details |
| ILB-202 | ILB-202; ILB202 | Phase 1 Clinical | Ilias Biologics Inc | Acute Kidney Injury; Intraoperative Complications | Details |
| human growth hormone (Yifan Pharma) | Phase 1 Clinical | Yifan Pharmaceutical (Shanghai) Co Ltd | Failure to Thrive; Growth Disorders; Growth hormone deficiency | Details | |
| MAR-002 | MAR002; MAR-002 | Phase 1 Clinical | Mareas Therapeutic Services Inc | Acromegaly | Details |
| Somatropin biosimilar (Jilin Qijian BioPharma) | Phase 1 Clinical | Jilin Qijian Bio-Pharmaceutical Co Ltd | Gonadal Dysgenesis; Growth Disorders; Growth hormone deficiency; Noonan Syndrome; Renal Insufficiency, Chronic | Details | |
| Human growth hormone-FC fusion protein(Changchun Institute Of Biological) | Phase 1 Clinical | Changchun Institute Of Biological Products Co Ltd | Growth hormone deficiency | Details | |
| Somatotropin biobetter (Ahn-Gook Pharma) | AG B1512; AG-B1512 | Phase 1 Clinical | Ahn-Gook Pharmaceutical Co Ltd | Growth Disorders | Details |
| Recombinant human growth factor-Fc fusion protein (Yifan Pharmaceutical) | F-899 | Phase 1 Clinical | Yifan Pharmaceutical Research Institute (Beijing) Co Ltd | Growth hormone deficiency | Details |
| Somatropin biosimilar (Bio-Ker) | Phase 1 Clinical | Bio-Ker Srl | Details | ||
| Somatropin polysialic (Xenetic Biosciences/SynBio) | SYN-20100504RU | Clinical | Xenetic Biosciences Inc | Growth hormone deficiency | Details |
| Recombinant human growth hormone (Kexing) | GB06; GB-06 | Clinical | Shenzhen Kexing Pharmaceutical Co Ltd | Details | |
| Long-Acting Growth Hormone (LAGH) | Clinical | University Of Minnesota | Growth hormone deficiency | Details | |
| Somatropin biosimilar (Reliance Life Sciences) | R-TPR-007 | Clinical | Reliance Life Sciences | Growth hormone deficiency | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Recombinant human growth hormone (GeneScience Pharmaceuticals) | Approved | Changchun GeneScience Pharmaceuticals Co Ltd | Jintropin AQ, 赛增, Jintropin | Mainland China | Growth Disorders; Growth hormone deficiency; Burns | Changchun GeneScience Pharmaceuticals Co Ltd | 1998-01-01 | Achondroplasia; Burns; Dwarfism; Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Infant, Premature, Diseases; Noonan Syndrome; Prader-Willi Syndrome; Short Bowel Syndrome; Turner Syndrome | Details | |
| Somatropin biosimilar (Amega Biotech) | Approved | Amega Biotech | Growth hormone deficiency | Details | ||||||
| Somatropin biosimilar (USV) | Approved | Union Square Ventures Llc | Growth hormone deficiency | Details | ||||||
| Somapacitan | NNC0195-0092; 8FOJ430U94 (UNII code); NN-8640 | Approved | Novo Nordisk A/S | Sogroya, 诺泽优 | United States | Growth hormone deficiency | Novo Nordisk Inc | 2020-08-28 | Bone Diseases, Endocrine; Dwarfism; Failure to Thrive; Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Noonan Syndrome; Turner Syndrome | Details |
| Somatropin (rDNA origin, Novo Nordisk) | NNLiquid-1519; B-hGH; NN-220; NN-1610; YM-17798; NNLiquid-1516; NNLiquid-1517; NNLiquid-1518; NN-701 | Approved | Novo Nordisk A/S | 诺泽, 诺浩, Norditropin | Mainland China | Growth hormone deficiency; Growth Disorders | Novo Nordisk A/S | 1999-06-22 | Anorexia Nervosa; Athletic Injuries; Bone Diseases, Endocrine; Bone Diseases, Metabolic; Brain Concussion; Brain Injuries, Traumatic; Dwarfism, Pituitary; Failure to Thrive; Fetal Growth Retardation; Fractures, Bone; Genetic Diseases, Inborn; Growth Disorders; Growth hormone deficiency; Hypopituitarism; Idiopathic short stature; Kidney Failure, Chronic; Noonan Syndrome; Prader-Willi Syndrome; Premature Birth; Puberty, Delayed; Renal Insufficiency, Chronic; Turner Syndrome | Details |
| Somatropin biosimilar (Sedico) | Approved | Sedico | Growth hormone deficiency; Turner Syndrome | Details | ||||||
| Somatropin biosimilar (Chalver Laboratorios) | Approved | Chalver Laboratorios | Biotropin | Colombia | Growth hormone deficiency | Chalver Laboratorios | 2012-10-01 | Growth hormone deficiency | Details | |
| Somatropin biosimilar (BioPartners GmbH) | rhGH (BioPartners GmbH); SR-rhGH (BioPartners GmbH); LB-03002 | Approved | Biopartners Gmbh, Lg Chemical Ltd | Valtropin | Mainland China | Growth hormone deficiency | Lg Chemical Ltd | 2006-04-24 | Dwarfism, Pituitary; Growth hormone deficiency; Pituitary Diseases; Prader-Willi Syndrome; Turner Syndrome | Details |
| Givopegsomatropin | GenSci-004 | Approved | Changchun GeneScience Pharmaceuticals Co Ltd | Jintrolong, 金赛增 | Mainland China | Growth hormone deficiency; Growth Disorders | Changchun GeneScience Pharmaceuticals Co Ltd | 2014-01-06 | Dwarfism; Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Turner Syndrome | Details |
| Somatropin (Dong-A ST) | DA-3002 | Approved | Dong-A ST Co Ltd | Growtropin | South Korea | Dwarfism; Idiopathic short stature | Dong-A ST Co Ltd | 1995-07-01 | Dwarfism; Idiopathic short stature; Premature Birth; Turner Syndrome | Details |
| Somatropin (rDNA origin, Merck Serono) | SJ-0011 | Approved | Merck Serono | 思真, Saizen, Serostim, Zorbtive, Serostim LQ | United States | Short Bowel Syndrome | Emd Serono Inc | 1996-08-23 | Achondroplasia; Failure to Thrive; Fibromyalgia; Growth Disorders; Growth hormone deficiency; HIV Infections; HIV Wasting Syndrome; HIV-Associated Lipodystrophy Syndrome; Idiopathic short stature; Short Bowel Syndrome | Details |
| Somatropin (JCR Pharmaceuticals) | JR-401A; JR-401X; JR-401S; hGH; JR-142 | Approved | Jcr Pharmaceuticals Co Ltd, Savient Pharmaceuticals Inc | Cryotropin, Zomacton, Tev-Tropin, SciTropin, Bio-tropin, Growject | United States | Growth Disorders; Growth hormone deficiency | Ferring Pharmaceuticals Ltd | 1995-05-25 | Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Turner Syndrome | Details |
| Somatropin (Lilly) | LY-137998 | Approved | Eli Lilly And Company | Humatrope, Umatrope | United States | Turner Syndrome; Growth Disorders; Idiopathic short stature; Growth hormone deficiency | Eli Lilly And Company | 1986-10-16 | Crohn Disease; Cystinosis; Dwarfism; Failure to Thrive; Gonadal Dysgenesis; Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Malnutrition; Muscular Diseases; Osteogenesis Imperfecta; Premature Birth; Turner Syndrome | Details |
| Inpegsomatropin | Approved | Xiamen Amoytop Biotech Co Ltd | 益佩生 | Mainland China | Growth hormone deficiency | Xiamen Amoytop Biotech Co Ltd | 2025-05-27 | Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Premature Birth | Details | |
| Lonapegsomatropin | ACP-011 | Approved | Ascendis Pharma | Skytrofa, 维臻高 | United States | Growth hormone deficiency | Ascendis Pharma Endocrinology Division As | 2021-08-25 | Deficiency Diseases; Dwarfism, Pituitary; Endocrine System Diseases; Growth hormone deficiency; Idiopathic short stature; Pituitary Diseases; Turner Syndrome | Details |
| Somatropin biosimilar (Anhui Anke Biotechnology) | Approved | Anhui Anke Biotechnology (Group) Co Ltd | 安苏萌 | Mainland China | Growth hormone deficiency; Burns | Anhui Anke Biotechnology (Group) Co Ltd | 1999-01-01 | Burns; Growth hormone deficiency; Idiopathic short stature; Turner Syndrome | Details | |
| Recombinant human growth hormone (Shanghai United Cell Biotechnology) | Approved | Shanghai United Cell Biotechnology Co Ltd | Genheal, 珍怡 | Mainland China | Growth Disorders | Shanghai United Cell Biotechnology Co Ltd | 1999-01-01 | Failure to Thrive; Growth Disorders; Growth hormone deficiency | Details | |
| Somatropin (rDNA origin, Pfizer) | Approved | Pfizer Inc | Genotropin Miniquick, Genotropin, 健豪宁 | United States | Prader-Willi Syndrome; Dwarfism; Turner Syndrome; Growth Disorders | Pharmacia | 1995-08-24 | Arthritis, Juvenile; Brain Concussion; Brain Injuries, Traumatic; Burns; Cognition Disorders; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Dwarfism; Endocrine System Diseases; Failure to Thrive; Fatigue; Fetal Growth Retardation; Growth Disorders; Growth hormone deficiency; Idiopathic short stature; Post-Concussion Syndrome; Prader-Willi Syndrome; Premature Birth; Turner Syndrome | Details | |
| Recombinant Human Growth Hormone for Injection (Zhongshan Sinobioway Hygene Biomedicine) | Approved | Zhongshan Sinobioway Hygene Biomedicine Co Ltd | 海之元, Sinotropin | Mainland China | Growth Disorders; Growth hormone deficiency | Zhongshan Sinobioway Hygene Biomedicine Co Ltd | 2005-03-23 | Growth Disorders; Growth hormone deficiency | Details | |
| Somatropin biosimilar (SICOR Biotech UAB) | Approved | Teva Pharmaceutical Industries Ltd | Somatogen-L | Lithuania | Growth hormone deficiency | Teva Pharmaceutical Industries Ltd | 1994-01-01 | Growth hormone deficiency | Details | |
| Somatrogon | PF-06836922; MOD-401; MOD-4023; hGH-CTP | Approved | Opko Health Inc | Ngenla, Lagova | Canada | Growth hormone deficiency | Pfizer Canada Ulc | 2021-10-26 | Growth Disorders; Growth hormone deficiency; Idiopathic short stature | Details |
| Recombinant human growth hormone (Daewoong Pharmaceutical) | Approved | Daewoong Pharmaceutical Co Ltd | Caretropin | South Korea | Growth hormone deficiency | Daewoong Pharmaceutical Co Ltd | 2012-01-01 | Growth hormone deficiency | Details | |
| Pegvisomant | G120K-PEG; B2036-PEG | Approved | Pfizer Inc | Trovert, Somavert | EU | Acromegaly | Pfizer Europe Ma Eeig | 2002-11-12 | Acromegaly; Diabetes Mellitus; Fibrous Dysplasia, Polyostotic; Insulin Resistance; Metabolic Syndrome; Pituitary Diseases | Details |
| Recombinant human somatropin (Novell Pharmaceutical Laboratories) | Approved | Novell Pharmaceutical Laboratories | Novell-Eutropin | Dwarfism; Growth hormone deficiency; Turner Syndrome | Details | |||||
| Somatropin biosimilar (Pharmstandard/Masterclone/CJSC Generium) | Approved | Cjsc Generium, Masterclone, Pharmstandard | Rastan | Growth hormone deficiency | null | 2008-01-01 | Growth hormone deficiency | Details | ||
| Somatropin biosimilar (Sandoz) | Approved | Sandoz | Omnitrope | EU | Dwarfism, Pituitary; Prader-Willi Syndrome; Turner Syndrome | Sandoz Gmbh | 2006-04-12 | Deficiency Diseases; Dwarfism, Pituitary; Growth hormone deficiency; Hypopituitarism; Idiopathic short stature; Prader-Willi Syndrome; Turner Syndrome | Details | |
| Recombinant human growth hormone (Shenzhen Kexing Biotech) | Approved | Shenzhen Kexing Biological Engineering Co Ltd | 赛高路, Sai Gao Lu | Mainland China | Growth hormone deficiency | Shenzhen Kexing Biological Engineering Co Ltd | 2002-06-24 | Failure to Thrive; Growth Disorders; Growth hormone deficiency | Details | |
| Recombinant human growth hormone (BioGeneric Pharma) | Approved | Biogeneric Pharma | Growth hormone deficiency | Biogeneric Pharma | 2013-01-01 | Growth hormone deficiency | Details | |||
| Somatropin (rDNA origin, Genentech) | rhGH (Genentech); SMP-140 | Approved | Genentech Inc | Nutropin, NutropinAq, Nutropin AQ | United States | Growth hormone deficiency | Genentech Inc | 1993-11-17 | Anorexia Nervosa; Bone Diseases, Metabolic; Cystic Fibrosis; Dwarfism; Dwarfism, Pituitary; Feeding and Eating Disorders; Growth Disorders; Growth hormone deficiency; Heart Failure; HIV Infections; Hypopituitarism; Kidney Diseases; Kidney Failure, Chronic; Mucopolysaccharidosis I; Mucopolysaccharidosis II; Mucopolysaccharidosis VI; Myocardial Ischemia; Obesity; Osteoporosis; Renal Insufficiency, Chronic; Turner Syndrome | Details |