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GCGR

GCGR

GCGR 詳細

Molecule Name
Glucagon receptor
分子の別称
Glucagon R, GCGR,Glucagon receptor
Drug Development Progress
治験薬の数40
市販薬剤の数6
研究＆開発段階Approved
ターゲットの別称
GL-R，GCGR，Glucagon Receptor，GGR，Receptors， Glucagon
バックグランド
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of  type 2 diabetes mellitus (T2DM) . The ever increasing prevalence of type 2 diabetes mellitus in the developed and developing nations calls for the introduction of new and more effective treatments. Glucagon receptor (GCGR) antagonists are highly validated in preclinical models of T2DM and thus have the potential to be developed as a new therapy.

GCGR 製品リスト

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治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
PRT-001PRT-001Phase 3 ClinicalParticle Therapeutics
Hypoglycemia
詳細
RetatrutideLY-3437943Phase 3 ClinicalEli Lilly And Company
Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hepatic Insufficiency; Insulin Resistance; Liver Diseases; Low Back Pain; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Osteoarthritis, Knee; Overweight; Renal Insufficiency; Renal Insufficiency, Chronic; Sleep Apnea, Obstructive
詳細
SurvodutideBI-456906; BI-456909Phase 3 ClinicalZealand Pharma A/S
Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Hepatitis; Liver Cirrhosis; Liver Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight; Renal Insufficiency; Renal Insufficiency, Chronic
詳細
BioGlutideNA-931Phase 3 ClinicalBiomed Industries Inc
Body Weight; Body Weight Changes; Diabetes Mellitus; Diabetes Mellitus, Type 2; Obesity; Overweight; Weight Loss
詳細
PemvidutideALT-801(Altimmune); SP-1373; VPD-107Phase 2 ClinicalVelocity Pharmaceutical Development
Alcoholism; Diabetes Mellitus, Type 2; Liver Diseases, Alcoholic; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
EfinopegdutideJNJ-64565111; HM-12525A; JNJ-5111; MK-6024Phase 2 ClinicalHanmi Pharmaceutical Co Ltd
Diabetes Mellitus, Type 2; Hepatic Insufficiency; Kidney Failure, Chronic; Liver Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity
詳細
EfocipegtrutideHM-15211Phase 2 ClinicalHanmi Pharmaceutical Co Ltd
Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity
詳細
volagidemabAMG-477; REMD-477Phase 2 ClinicalAmgen Inc
Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose Intolerance; Hyperglycemia; Insulin Resistance; Iron deficiency
詳細
IsosteviolISV; STX-03Phase 2 ClinicalStevia Pharma
Diabetes Mellitus, Type 2
詳細
GlucagonMP-123456BPhase 2 ClinicalEli Lilly And Company
Diabetes Mellitus; Diabetes Mellitus, Type 1; Hypoglycemia
詳細
Oxyntomodulin long-acting (Pharmsynthez/Xenetic Biosciences)Phase 2 ClinicalPharmsynthez, Xenetic Biosciences Inc
Diabetes Mellitus, Type 2; Obesity
詳細
IONIS-GCGRRxIONIS-GCGRRx; ISIS-449884; ISISGCGRRxPhase 2 ClinicalIonis Pharmaceuticals Inc
Diabetes Mellitus, Type 2
詳細
EfpegerglucagonHM-15136Phase 2 ClinicalHanmi Pharmaceutical Co Ltd
Congenital Hyperinsulinism; Diabetes Mellitus, Type 2; Obesity
詳細
UBT-251UBT251; UBT-251Phase 2 ClinicalLianbang Biotechnology (Zhuhai Hengqin) Co Ltd
Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight; Renal Insufficiency; Renal Insufficiency, Chronic; Sleep Apnea, Obstructive
詳細
AZD9550AZD9550; AZD-9550Phase 2 ClinicalAstrazeneca Plc
Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
MWN-109MWN-109Phase 2 ClinicalShanghai Minwei Biotechnology Co Ltd
Body Weight; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
MWN-101MWN-101Phase 2 ClinicalShanghai Minwei Biotechnology Co Ltd
Diabetes Mellitus, Type 2; Obesity; Overweight; Sleep Apnea, Obstructive
詳細
RBD-4988RBD-4988Phase 2 ClinicalSuzhou Ribo Life Science Co Ltd
Diabetes Mellitus, Type 2
詳細
ZX-2021ZX-2021; ZX2021Phase 2 ClinicalJiangsu Zhongxin Pharmaceutical Co Ltd
Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
DR-10624DR-10624; DR10624Phase 2 ClinicalZhejiang Doer Biologics Corp
Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight
詳細
PB-718PB-718Phase 2 ClinicalPeg Bio Co Ltd
Congenital Hyperinsulinism; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
TB-001TB001; TB-001Phase 2 ClinicalShenzhen Turier Biotech Co Ltd
Cholangitis, Sclerosing; Hepatitis B, Chronic; Liver Cirrhosis; Metabolic Dysfunction-Associated Steatotic Liver Disease
詳細
DD-01DD-01Phase 2 ClinicalD&D Pharmatech
Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
CotadutideMEDI-0382Phase 2 ClinicalMedimmune Llc
Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Hepatic Insufficiency; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Renal Insufficiency; Renal Insufficiency, Chronic
詳細
Glucagon (rDNA origin, Lilly)Phase 1 ClinicalEli Lilly And Company
Diabetes Mellitus, Type 1; Hypoglycemia; Insulin Resistance; Obesity
詳細
Glucagon (Translational Research Institute for Metabolism and Diabetes, Florida)Phase 1 ClinicalTranslational Research Institute For Metabolism And Diabetes
Obesity
詳細
Glucagon agonist (Imperial college London)Phase 1 ClinicalImperial College London
Obesity
詳細
glucagon (Therakind)Phase 1 ClinicalTherakind Ltd
Hypoglycemia
詳細
PRT-003PRT-003Phase 1 ClinicalParticle Therapeutics
詳細
GGG Tri-Agonist III (Lilly)Phase 1 ClinicalEli Lilly And Company
Cardiovascular Diseases
詳細
DYX-116DYX116; DYX-116Phase 1 ClinicalJiangsu Deyuan Pharmaceutical Co Ltd
Diabetes Mellitus, Type 2; Obesity; Overweight
詳細
KAI-4729HRS-4729; KAI-4729Phase 1 ClinicalJiangsu Hengrui Medicine Co Ltd
Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
XTL-6001XTL-6001; XTL6001Phase 1 ClinicalShanghai Xizaili Biomedical Technology Co Ltd
Obesity; Overweight; Proteinuria; Renal Insufficiency, Chronic
詳細
NN-6177NN-6177Phase 1 ClinicalNovo Nordisk A/S
Metabolic Dysfunction-Associated Steatotic Liver Disease
詳細
Glucagon/insulin human(Abvance Therapeutics)ABV-100Phase 1 ClinicalAbvance Therapeutics
Hypoglycemia
詳細
PB-722PB722; PB-722Phase 1 ClinicalPeg Bio Co Ltd
Congenital Hyperinsulinism
詳細
CMS-D005CMS-D005Phase 1 ClinicalChina Medical System Holdings Ltd
Metabolic Diseases; Obesity; Overweight
詳細
TY-751TY-751; TY751Phase 1 ClinicalTianjin Remedy Research Institute
Diabetes Mellitus; Diabetes Mellitus, Type 2; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight
詳細
DA-1726DA-1726Phase 1 ClinicalDong-A ST Co Ltd
Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity
詳細
SHR-1816SHR1816; SHR-1816Phase 1 ClinicalBeijing Suncadia Medicine Co Ltd
Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Glucagon (rDNA origin, Novo Nordisk)GL-GApprovedNovo Nordisk A/SGlucaGen, Glucagon GJapanHypoglycemiaNovo Nordisk A/S1996-05-01
Diabetes Mellitus, Type 1; Gastrointestinal Diseases; Hypoglycemia; Obesity
詳細
DasiglucagonZP-GA-1; ZP-4207ApprovedZealand Pharma A/SZegalogueUnited StatesHypoglycemiaZealand Pharma Us Inc2021-03-22
Congenital Hyperinsulinism; Diabetes Mellitus; Diabetes Mellitus, Type 1; Glucose Metabolism Disorders; Hyperinsulinism; Hypoglycemia
詳細
MazdutideOXM-3; IBI-362; LY-3305677ApprovedEli Lilly And Company信尔美Mainland ChinaObesity; OverweightInnovent Biologics(Suzhou) Co Ltd2025-06-24
Alcoholism; Diabetes Mellitus, Type 2; Heart Failure; Heart Failure, Diastolic; Hypertension; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Overweight; Renal Insufficiency; Sleep Apnea Syndromes; Sleep Apnea, Obstructive
詳細
Glucagon intranasal (Eli Lilly/Locemia Solutions)AMG504-1; LY-900018ApprovedAmg Medical, Locemia SolutionsBaqsimiUnited StatesHypoglycemiaAmphastar Pharmaceuticals Inc2019-07-24
Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hypoglycemia
詳細
Glucagon (Xeris Pharmaceuticals)ApprovedXeris Pharmaceuticals IncGvoke, Ogluo, GVOKE VialDxUnited StatesHypoglycemiaXeris Pharmaceuticals Inc2019-09-10
Hyperinsulinism; Hypoglycemia
詳細
Glucagon (Tetris)ApprovedTetris Pharma LtdOgluoEUHypoglycemiaTetris Pharma Ltd2021-02-11
Hypoglycemia
詳細