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Flt-3

Flt-3信息

英文名称:Tyrosine-protein kinase receptor FLT3上市药物数量13
中文名称酪氨酸蛋白激酶受体FLT3临床药物数量57
靶点别称EC:2.7.10.1，CD135 Antigen，CD135，STK1，Growth Factor Receptor Tyrosine Kinase Type III，Fms-Related Tyrosine Kinase 3，Fetal Liver Kinase 2，Fetal Liver Kinase-2，EC 2.7.10.1，fms-Like Tyrosine Kinase 3，Receptor-type tyrosine-protein kinase FLT3，FLT3，FLT-3，FLK2，STK-1，FL cytokine receptor，Fms Related Tyrosine Kinase 3，Stem Cell Tyrosine Kinase 1，FLK-2，Fms Related Receptor Tyrosine Kinase 3，EC 2.7.10最高研发阶段临床三期
英文名称:Tyrosine-protein kinase receptor FLT3
中文名称酪氨酸蛋白激酶受体FLT3
靶点别称EC:2.7.10.1，CD135 Antigen，CD135，STK1，Growth Factor Receptor Tyrosine Kinase Type III，Fms-Related Tyrosine Kinase 3，Fetal Liver Kinase 2，Fetal Liver Kinase-2，EC 2.7.10.1，fms-Like Tyrosine Kinase 3，Receptor-type tyrosine-protein kinase FLT3，FLT3，FLT-3，FLK2，STK-1，FL cytokine receptor，Fms Related Tyrosine Kinase 3，Stem Cell Tyrosine Kinase 1，FLK-2，Fms Related Receptor Tyrosine Kinase 3，EC 2.7.10
上市药物数量13
临床药物数量57
最高研发阶段Phase 3 Clinical

Flt-3产品列表

  • 属性

    Protein (6)

  • 产品库

    在线 (7)

  • 物种

    Human (4)Mouse (1)Cynomolgus (1)

  • 标签

    Fc Tag (2)His Tag (3)His Tag & Avi Tag (1)

  • 标记

    Unconjugated (4)Biotin-labeled (1)FITC Labeled (1)

共 6 项数据
  • 1

Flt-3分子背景

Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Flt-3分子别名

Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

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