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FAP

FAP信息

英文名称:Prolyl endopeptidase FAP上市药物数量0
中文名称成纤维细胞激活蛋白α临床药物数量45
靶点别称Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP最高研发阶段Phase 2 Clinical
英文名称:Prolyl endopeptidase FAP
中文名称成纤维细胞激活蛋白α
靶点别称Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP
上市药物数量0
临床药物数量45
最高研发阶段Phase 2 Clinical

FAP产品列表

  • 属性

    Protein (11)Beads (1)Cell (1)

  • 产品库

    在线 (13)

  • 物种

    Human (8)Cynomolgus (2)Mouse (2)Rat (1)

  • 标签

    His Tag (6)Fc Tag (2)His Tag & Avi Tag (3)- (2)

  • 标记

    Unconjugated (5)FITC Labeled (2)Biotin-labeled (3)PE Labeled (1) (2)

共 13 项数据
  • 1
  • 2

FAP分子背景

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP分子别名

FAP,FAPalpha,SIMP,Seprase,APCE

产品评论

  • ga*******126.com 2025-02-25
    0人点赞
    Mouse FAP Protein, His Tag, active dimer (MALS verified)
    购买该鼠源FAP蛋白主要目的是用于免疫和筛选相关的纳米抗体。蛋白活性稳定，在一系列生物化学检测和结合实验中，数据都很稳定。免疫期间毒副作用小，动物状态良好，血清效价很不错，为我们纳米抗体研发奠定了坚实的基础。
  • ga*******126.com 2025-02-25
    0人点赞
    Cynomolgus FAP Protein, His Tag, active dimer (MALS verified)
    购买该蛋白主要用于噬菌体展示抗体库的筛选及抗体活性检测。产品以冻干粉形式提供，便于储存和运输，且重构方法简单，适合各种实验室条件。蛋白活性及纯度都很不错，相比同类产品，ACRO的重组蛋白在保证高质量的同时，价格具有竞争力，为我们提供了一个高性价比的选择。
  • tm*****sina.cn 2025-02-19
    0人点赞
    Biotinylated Cynomolgus FAP Protein, His,Avitag™, active dimer (MALS verified)
    我们购买的这个Acro蛋白是biotin标记的猴蛋白，用于抗体的筛选和结合实验。多次购买，生产的质量很稳定。同时这是一个trimer蛋白，需要改造进行稳定构象。有稳定的质量，Acro生产的很不错。
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