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CD23

CD23信息

英文名称:Immunoglobulin epsilon Fc receptor上市药物数量0
中文名称免疫球蛋白ε-Fc受体临床药物数量2
靶点别称Low affinity immunoglobulin epsilon Fc receptor，FCE2，CD23A，FCER2，CLEC4J，BLAST-2，Fc Fragment Of IgE Receptor II，C-Type Lectin Domain Family 4， Member J，Immunoglobulin Epsilon-Chain，CD23，Lymphocyte IgE Receptor，Fc Epsilon Receptor II，Fc-Epsilon-RII，CD23 Antigen，IGEBF，Fc Fragment Of IgE， Low Affinity II， Receptor For (CD23A)，C-Type Lectin Domain Family 4 Member J，Immunoglobulin E-binding factor，Fc Fragment Of IgE， Low Affinity II， Receptor For (CD23)最高研发阶段临床二期
英文名称:Immunoglobulin epsilon Fc receptor
中文名称免疫球蛋白ε-Fc受体
靶点别称Low affinity immunoglobulin epsilon Fc receptor，FCE2，CD23A，FCER2，CLEC4J，BLAST-2，Fc Fragment Of IgE Receptor II，C-Type Lectin Domain Family 4， Member J，Immunoglobulin Epsilon-Chain，CD23，Lymphocyte IgE Receptor，Fc Epsilon Receptor II，Fc-Epsilon-RII，CD23 Antigen，IGEBF，Fc Fragment Of IgE， Low Affinity II， Receptor For (CD23A)，C-Type Lectin Domain Family 4 Member J，Immunoglobulin E-binding factor，Fc Fragment Of IgE， Low Affinity II， Receptor For (CD23)
上市药物数量0
临床药物数量2
最高研发阶段Phase 2 Clinical

CD23产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    His Tag & Avi Tag (1)His Tag (1)

  • 标记

    Biotin-labeled (1)Unconjugated (1)

共 2 项数据
  • 1

CD23分子背景

Cluster of differentiation 23 (CD23) is also known as Low affinity immunoglobulin epsilon Fc receptor (FCER2), C-type lectin domain family 4 member J (CLEC4J), Fc-epsilon-RII (FcεRII), Immunoglobulin E-binding factor (IGEBF), is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. CD23 is known to have role of transportation in antibody feedback regulation. Antigen that enters the blood stream is captured by antigen specific IgE antibodies. The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response. In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative).

CD23分子别名

FCER2,CD23,CD23A,CLEC4J,FCE2,IGEBF,FcεRII,FcεRⅡ

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