BDNF Overview
Molecule Name
Brain-derived neurotrophic factor
Synonyms
BDNF,ANON2,BULN2,Abrineurin
Drug Development Progress
Drugs in Clinical Trials8
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
Brain-Derived Neurotrophic Factor，Abrineurin，ANON2，Brain Derived Neurotrophic Factor，BULN2，ProBDNF，Neurotrophin
Background
Brain-derived neurotrophic factor (BDNF) along with nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) are members of the neurotrophin family of trophic factors. The neurotrophins play essential roles in the development, survival, and function of a wide range of neurons in both the peripheral and central nervous systems. The neurotrophins interact with two cell surface receptors, the low affinity P75 receptor and the Trk family of high affinity tyrosine kinase receptors. NGF preferentially binds TrkA, BDNF and NT4/5 bind TrkB, and NT-3 binds TrkC (and TrkA to a lesser extent).
BDNF Product List
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Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Tetramethylpyrazine Nitrone | Phase 3 Clinical | Jinan University | Amyotrophic Lateral Sclerosis; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Ischemic Stroke | Details | |
| JS1-1-01 | JS1-1-01 | Phase 3 Clinical | Tianjin Tasly Pharmaceutical Co Ltd | Depression; Depressive Disorder; Depressive Disorder, Major | Details |
| ACT-01 | ACT-01; OCS-05; BN-201; G-79 | Phase 2 Clinical | Promius Pharma | Keratosis, Actinic; Optic Neuritis | Details |
| Aldifen | MP101; NSC-1532; MP-101 | Phase 2 Clinical | Mitochon Pharmaceuticals | Amyotrophic Lateral Sclerosis; Huntington Disease; Multiple Sclerosis | Details |
| ALTO-100 | ALTO-100 | Phase 2 Clinical | Alto Neuroscience Inc | Bipolar I Disorder; Bipolar II Disorder; Depressive Disorder, Major; Stress Disorders, Post-Traumatic | Details |
| AC-102 | AC-102 | Phase 2 Clinical | AudioCure Pharma GmbH | Hearing Loss, Sensorineural; Hearing Loss, Sudden; Tinnitus | Details |
| Laquinimod Sodium | TV-5600; ABR-215062; SAIK-MS | Phase 1 Clinical | Active Biotech Ab | Arthritis; Crohn Disease; Eye Diseases; Huntington Disease; Lupus Nephritis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Uveitis | Details |
| AAV2-BDNF gene therapy (University Of California San Diego) | Phase 1 Clinical | University Of California San Diego | Alzheimer Disease; Cognitive Dysfunction | Details |