B7-H3 (4Ig) 詳細
Molecule Name
CD276 antigen
分子の別称
4Ig-B7-H3,B7-H3,CD276,PSEC0249,UNQ309,PRO352,B7 homolog 3
Drug Development Progress
治験薬の数72
市販薬剤の数0
研究＆開発段階NDA/BLA
ターゲットの別称
B7 homolog 3，PSEC0249，UNQ309/PRO352，B7-H3，CD276 antigen，B7H3，CD276，CD276 Molecule，Costimulatory Molecule，4Ig-B7-H3，B7RP-2
バックグランド
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
B7-H3 (4Ig) 製品リスト
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治験薬に関する情報
| 英語名 | 研究コード | 研究開発ステージ | 会社 | 適応症 | 臨床試験 |
|---|---|---|---|---|---|
| Ifinatamab deruxtecan | I-DXd; DS-7300a; DS-7300; MABX-9001a; MK-2400 | Phase 3 Clinical | Daiichi Sankyo Co Ltd | Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Neoplasm Metastasis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| MHB-088C | MHB-088C; QLC-5508; QLC5508; MHB088C | Phase 3 Clinical | Minghui Pharmaceutical Pty Ltd | Esophageal Squamous Cell Carcinoma; Prostatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| DB-1311 | BNT-324; DB-1311 | Phase 3 Clinical | Duality Biologics (Suzhou) Co Ltd | Lung Neoplasms; Neoplasm Metastasis; Prostatic Neoplasms, Castration-Resistant; Solid tumours | 詳細 |
| YL-201 | YL-201; YL201 | Phase 3 Clinical | MediLink Therapeutics Co Ltd | Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Lung Diseases; Nasopharyngeal Carcinoma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Solid tumours; Thoracic Neoplasms | 詳細 |
| Risvutatug Rezetecan | HS-20093; HS20093; GSK5764227; GSK-5764227; GSK’227 | Phase 3 Clinical | Shanghai Hansoh Biomedical Co Ltd | Adenocarcinoma; Brain metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Glioblastoma; Lung Neoplasms; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Small Cell Lung Carcinoma; Soft Tissue Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms | 詳細 |
| B7-H3 CAR-T cell therapy (Boyuan Runsheng Pharma) | Phase 2 Clinical | Boyuan Runsheng Pharma (Hangzhou) Co Ltd | Glioblastoma; Solid tumours | 詳細 | |
| Obrindatamab | MGD-009; B7-H3 x CD3 | Phase 2 Clinical | Macrogenics Inc | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Melanoma; Mesothelioma; Neuroblastoma; Neurofibrosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma; Sarcoma, Synovial; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor | 詳細 |
| Vobramitamab duocarmazine | MGC-018 | Phase 2 Clinical | Macrogenics Inc | Anus Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Small Cell; Hormone-Resistant Prostate Neoplasms; Laryngeal Neoplasms; Melanoma; Oral Squamous Cell Carcinoma; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck | 詳細 |
| SJCARB7H3_41BBL | SJCARB7H3_41BBL | Phase 2 Clinical | St. Jude Children'S Research Hospital | Adrenocortical Carcinoma; Carcinoma; Desmoplastic Small Round Cell Tumor; Hepatoblastoma; Melanoma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neurofibrosarcoma; Osteosarcoma; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Clear Cell; Sarcoma, Ewing; Solid tumours; Wilms Tumor | 詳細 |
| SPGL-008 | SPGL008; SPGL-008 | Phase 2 Clinical | Shenzhen Sciprogen Bio-Pharmaceutical Co Ltd | Neoplasms; Urinary Bladder Neoplasms | 詳細 |
| GD2/B7H3 CAR T-cell therapy(Yake Biotechnology) | Phase 2 Clinical | Shanghai YaKe Biotechnology Co Ltd | Desmoplastic Small Round Cell Tumor; Neuroblastoma | 詳細 | |
| GenSci-143 | GenSci-143; GenSci143 | Phase 2 Clinical | Changchun GeneScience Pharmaceuticals Co Ltd | Alzheimer Disease; Prostatic Neoplasms, Castration-Resistant; Solid tumours | 詳細 |
| RV-01 | 177Lu-RV01; RV-01 | Phase 2 Clinical | Radiopharm Ventures | Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms | 詳細 |
| SYS-6043 | SYS6043; SYS-6043 | Phase 2 Clinical | Jushi Biopharmaceutical Co Ltd | Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck | 詳細 |
| SKB-500 | SKB500; SKB-500 | Phase 2 Clinical | Sichuan Kelun-Biotech Biopharmaceutical Co Ltd | Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| FH-006 | FH-006; FH006 | Phase 2 Clinical | Jiangsu Hengrui Medicine Co Ltd, Shanghai Fuhong Biomedical Co Ltd | Lung Neoplasms; Solid tumours | 詳細 |
| DB-1419 | DB-1419 | Phase 2 Clinical | Duality Biologics (Suzhou) Co Ltd | Solid tumours | 詳細 |
| IBI129 | IBI-129; IBI129 | Phase 2 Clinical | Solid tumours | 詳細 | |
| 7MW-3711 | 7-MW-3711; 7MW3711 | Phase 2 Clinical | Mabwell (Shanghai) Bioscience Co Ltd | Neoplasms; Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| IBI334 | IBI334; IBI-334 | Phase 2 Clinical | Solid tumours | 詳細 | |
| MT-027 | MT-027 | Phase 2 Clinical | T-Maximum Pharmaceutical (Suzhou) Co Ltd | Brain Neoplasms; CNS Embryonal Tumor; Glioblastoma; Glioma; Mesothelioma; Neoplasms; Nervous System Neoplasms; Peritoneal Neoplasms; Pleural Effusion, Malignant; Pleural Neoplasms; Solid tumours | 詳細 |
| IBB-0979 | IBB0979; IBB-0979 | Phase 2 Clinical | SunHo (China) BioPharmaceutical Co Ltd | Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Neoplasms; Peritoneal Neoplasms; Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| ILB-3101 | ILB-3101 | Phase 2 Clinical | Innolake Biopharm (Hangzhou) Co Ltd | Leukemia, Myeloid, Acute; Neoplasms; Solid tumours | 詳細 |
| Fully Human B7H3 CAR-T Cells Therapy | fhB7H3.CAR-Ts | Phase 2 Clinical | The Affiliated Hospital Of Xuzhou Medical University | Carcinoma, Hepatocellular; Ovarian Neoplasms | 詳細 |
| CD-276-targeted Chimeric Antigen Receptor T Cell Therapy | CD276 CAR-T | Phase 2 Clinical | Shenzhen University General Hospital | Pancreatic Neoplasms | 詳細 |
| Enoblituzumab | MGA-271; TJ271 | Phase 2 Clinical | Macrogenics Inc | Abdominal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Desmoplastic Small Round Cell Tumor; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Melanoma; Neoplasms; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Rhabdomyosarcoma; Sarcoma, Ewing; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor | 詳細 |
| SC-CAR4BRAIN | Phase 1 Clinical | Seattle Children'S Hospital | Carcinoma; Carcinoma, Hepatocellular; Central Nervous System Neoplasms; Desmoplastic Small Round Cell Tumor; Diffuse Intrinsic Pontine Glioma; Diffuse midline glioma; Endodermal Sinus Tumor; Hepatoblastoma; Liposarcoma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neurofibrosarcoma; Osteosarcoma; Retinoblastoma; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Clear Cell; Sarcoma, Ewing; Sarcoma, Synovial; Solid tumours; Wilms Tumor | 詳細 | |
| 124I-omburtamab | 124I-8H9; 124I-8H9-(B7-H3) | Phase 1 Clinical | Memorial Sloan Kettering Cancer Center, Y-Mabs Therapeutics Inc | Brain Neoplasms; Glioma | 詳細 |
| Mirzotamab clezutoclax | ABBV-155 | Phase 1 Clinical | Abbvie Inc | Solid tumours | 詳細 |
| B7-H3/IL-7Ra CAR T-cell therapy (Chulalongkorn University) | Phase 1 Clinical | Chulalongkorn University | Brain Neoplasms | 詳細 | |
| CAR.B7-H3 T cells | Phase 1 Clinical | Unc Lineberger Comprehensive Cancer Center | Carcinoma, Pancreatic Ductal; Fallopian Tube Neoplasms; Glioblastoma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms | 詳細 | |
| second generation anti-CD276 CAR T-cell therapy (Seattle Children's Hospital/Cureworks) | Phase 1 Clinical | Seattle Children'S Hospital | Carcinoma, Embryonal; Hepatoblastoma; Melanoma; Neoplasms; Neuroblastoma; Osteosarcoma; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Solid tumours; Wilms Tumor | 詳細 | |
| BCB-276 | SCRI-CARB7H3; SCRI-CARB7H3(s); BRAINCHILD-03; BCB-276 | Phase 1 Clinical | BrainChild Bio Inc | Central Nervous System Neoplasms; Glioma | 詳細 |
| CC-3 | CC-3 | Phase 1 Clinical | Eberhard Karls University Of Tubingen, Germany | Breast Neoplasms; Colorectal Neoplasms; Gastrointestinal Neoplasms; Penile Neoplasms; Sarcoma | 詳細 |
| ITC-6146RO | ITC6146RO | Phase 1 Clinical | Ab Studio Inc, IntoCell | Carcinoma, Non-Small-Cell Lung; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Triple Negative Breast Neoplasms | 詳細 |
| KT-095 | KT-095 | Phase 1 Clinical | Nanjing Kati Medical Technology Co Ltd | Solid tumours | 詳細 |
| EX-105 | EX-105; EX105 | Phase 1 Clinical | Guangzhou Excelmab Inc | Solid tumours | 詳細 |
| GTB-5550 | GTB-5550; B7H3 TriKE™; cam1615B7H3; GTB-5550 TriKE™ | Phase 1 Clinical | University Of Minnesota | Solid tumours | 詳細 |
| EPC-003 | EPC-003 | Phase 1 Clinical | Elpis BioPharmaceuticals Corp | Glioblastoma; Multiple Myeloma | 詳細 |
| EPC-002 | EPC-002 | Phase 1 Clinical | Elpis BioPharmaceuticals Corp | Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Pancreatic Neoplasms; Solid tumours; Urinary Bladder Neoplasms | 詳細 |
| B7-H3.CD28Z.CART cell therapy (National Institutes Of Health) | b7-h3.cd28z.Cart) | Phase 1 Clinical | National Institutes Of Health | Brain Neoplasms; Central Nervous System Neoplasms; Ependymoma; Medulloblastoma; Meningeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Pinealoma; Rhabdoid Tumor; Teratoma | 詳細 |
| B7-H3.CD28Z.CART therapy (Band Of Parents) | Phase 1 Clinical | The Band Of Parents | Neuroblastoma; Solid tumours | 詳細 | |
| NEOK-001 | NEOK001; NEOK-001; ABL206; ABL-206 | Phase 1 Clinical | Abl Bio Inc | Solid tumours | 詳細 |
| HLX-316 | HLX-316 | Phase 1 Clinical | Neoplasm Metastasis; Solid tumours | 詳細 | |
| DIT-309 | DIT309; DIT-309 | Phase 1 Clinical | Tcelltech Inc | Osteosarcoma; Sarcoma | 詳細 |
| TJ-101 (Phrontline Biopharma) | TJ-101 | Phase 1 Clinical | Phrontline Biopharma Co Ltd | Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Prostatic Neoplasms; Solid tumours | 詳細 |
| ICP-B794 | ICP-B794 | Phase 1 Clinical | Esophageal Neoplasms; Lung Neoplasms; Nasopharyngeal Carcinoma; Neoplasm Metastasis; Prostatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck | 詳細 | |
| QH-104A | QH104A; QH-104A | Phase 1 Clinical | Beijing Qinghui Liannuo Biotechnology Co Ltd | Central Nervous System Neoplasms; Glioma; Neoplasms | 詳細 |
| WL276 CAR-T Cell Therapy(Immunochina Medical Science & Technology) | Phase 1 Clinical | Imunopharm Technology Co Ltd | Glioblastoma | 詳細 | |
| IDE-034 | BCG034; IDE034; IDE-034 | Phase 1 Clinical | Colorectal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Solid tumours | 詳細 | |
| CAR.B7-H3 T cells (Unc Lineberger Comprehensive Cancer Center) | Phase 1 Clinical | Unc Lineberger Comprehensive Cancer Center | Glioblastoma | 詳細 | |
| SDTM-001 | SDTM-001; SDTM001 | Phase 1 Clinical | Sidet Biopharmaceutical Co Ltd | Carcinoma, Non-Small-Cell Lung | 詳細 |
| [68Ga] B7H3 Affibody-BCH(Beijing Cancer Hospital) | Phase 1 Clinical | Beijing Cancer Hospital | Neoplasms | 詳細 | |
| BGB-C354 | BGB-C354; BG-C354 | Phase 1 Clinical | BeOne Medicines Ltd | Gastrointestinal Neoplasms; Lung Neoplasms; Solid tumours | 詳細 |
| IBI-3001 | IBI-3001; IBI3001 | Phase 1 Clinical | Solid tumours | 詳細 | |
| MGC-026 | MGC026; MGC-026 | Phase 1 Clinical | Macrogenics Inc | Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 詳細 |
| Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) | Phase 1 Clinical | Chulalongkorn University, King Chulalongkorn Memorial Hospital | Brain Neoplasms; Diffuse Intrinsic Pontine Glioma; Neoplasms; Solid tumours | 詳細 | |
| iC9-CAR.B7-H3 T Cell Therapy (Unc Lineberger Comprehensive Cancer Center) | Phase 1 Clinical | Bellicum Pharmaceuticals Inc | Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms | 詳細 | |
| BB-1712 | BB-1712 | Phase 1 Clinical | Bliss Biopharmaceutical (Hangzhou) Co Ltd | Solid tumours | 詳細 |
| QH-104 | QH-104 | Phase 1 Clinical | Beijing Qinghui Liannuo Biotechnology Co Ltd | Glioma; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours | 詳細 |
| UTAA-06 | UTAA-06; UTAA06 | Phase 1 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd | Leukemia, Myeloid, Acute; Solid tumours | 詳細 |
| B7-H3 CAR T-cell therapy(Stanford University) | B7-H3CART | Phase 1 Clinical | Stanford University | Nervous System Diseases; Ovarian Neoplasms | 詳細 |
| TX-103 | TX-103 | Phase 1 Clinical | Fuzhou Tcelltech Biological Science and Technology Co Ltd | Glioma; Solid tumours | 詳細 |
| EGFR/B7H3 CAR-T | EGFR/B7H3 CAR-T | Phase 1 Clinical | Second Affiliated Hospital Of Guangzhou Medical University | Lung Neoplasms; Triple Negative Breast Neoplasms | 詳細 |
| B7-H3-targeting CAR-T cell therapy | Phase 1 Clinical | Beijing Tiantan Hospital, Capital Medical University | Glioblastoma | 詳細 | |
| BAT-8009 | BAT8009; BAT-8009 | Phase 1 Clinical | Bio-Thera Solutions Ltd | Solid tumours | 詳細 |
| TAA-06 | TAA-06; TAA06-UCAR-γδT | Phase 1 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd | Colorectal Neoplasms; Lung Neoplasms; Melanoma; Neuroblastoma; Solid tumours | 詳細 |
| XmAb-808 | XmAb808 | Phase 1 Clinical | Xencor Inc | Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Melanoma; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms | 詳細 |
| DXC-014 | DAC-014; DXC-014 | Phase 1 Clinical | Hangzhou Dac Biotech Company Ltd | Melanoma; Prostatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours | 詳細 |
| Anti-CD276 CAR T-cell therapy (Persongen ) | Phase 1 Clinical | Persongen Biotherapeutics (Suzhou) Co Ltd | Lung Neoplasms; Neuroblastoma; Osteosarcoma; Stomach Neoplasms | 詳細 | |
| anti-B7-H3 CAR T-cell therapy (Soochow T-Maximun Biotechnology/Second Affiliated Hospital of Soochow University) | Clinical | T-Maximum Pharmaceutical (Suzhou) Co Ltd | Glioma | 詳細 | |
| TX-103-CAR-T | TX-103-CAR-T | Clinical | Union Hospital Affiliated To Fujian Medical University | Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioma; Head and Neck Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms | 詳細 |