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ADORA2A

ADORA2A

ADORA2A 詳細

Molecule Name
Adenosine A2a receptor
分子の別称
ADORA2A,adenosine A2a receptor,A2aR, ADORA2, RDC8
Drug Development Progress
治験薬の数23
市販薬剤の数53
研究＆開発段階Approved
ターゲットの別称
Adenosine receptor A2a，ADORA2A，Adenosine A2a Receptor，ADORA2，Adenosine Receptor Subtype A2a，A2aR，RDC8，Receptor， Adenosine A2A
バックグランド
Adenosine Receptor Subtype A2a (ADORA2A) is a G-protein coupled adenosine receptor encoded by the ADORA2A gene. It is mainly involved in pathophysiological processes including neuroinflammation, synaptic plasticity in glutamatergic synapses and neurogenesis.

ADORA2A 製品リスト

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治験薬に関する情報

英語名研究コード研究開発ステージ会社適応症臨床試験
Naproxen/CaffeineBAY-2880376Phase 3 ClinicalBayer AG
Pain, Postoperative
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CiforadenantCPI-444; V-81444Phase 2 ClinicalVernalis (R&D) Ltd
Attention Deficit Disorder with Hyperactivity; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Multiple Myeloma; Neoplasms; Parkinson Disease
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CaffeinolPhase 2 ClinicalCardium Therapeutics
Alcoholic Intoxication; Alcoholism; Carcinoma, Non-Small-Cell Lung; Disruptive, Impulse Control, and Conduct Disorders; Ischemic Stroke
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EtrumadenantAB-928; GS-0928Phase 2 ClinicalArcus Biosciences Inc
Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Hormone-Resistant Prostate Neoplasms; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Melanoma; Mouth Neoplasms; Neoplasm Metastasis; Oral Squamous Cell Carcinoma; Oropharyngeal Neoplasms; Oropharyngeal Squamous Cell Carcinoma (OPSCC); Ovarian Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms
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PORT-8PORT-8; TT-53Phase 2 ClinicalTarus Therapeutics Inc
Solid tumours
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ND10(Theialife Inc)ND-10; ND10Phase 2 ClinicalTheialife Inc
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PORT-6PORT-6; TT-10Phase 2 ClinicalImpetis Biosciences Ltd
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MK-1088MK-1088Phase 2 ClinicalMerck Sharp & Dohme LLC
Solid tumours
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VG081821ACVG081821AC; VG-081821ACPhase 2 ClinicalZhejiang Vimgreen Pharmaceuticals Ltd
Metabolic Dysfunction-Associated Steatotic Liver Disease; Parkinson Disease
詳細
ILB-2109WTS-001; ILB-2109Phase 2 ClinicalHangzhou Wutong Tree Pharmaceutical Co Ltd
Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Melanoma; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms
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PBF-999PBF-999Phase 1 ClinicalPalobiofarma Sl
Huntington Disease; Neoplasms
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[18F]MNI-444[18F]MNI-444Phase 1 ClinicalInvicro Llc
Diagnostic agents
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SHR-5126SHR-5126Phase 1 ClinicalJiangsu Hengrui Medicine Co Ltd
Neoplasms
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TaminadenantNIR-178; PBF-509Phase 1 ClinicalPalobiofarma Sl
Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Triple Negative Breast Neoplasms
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ST-4206ST-4206Phase 1 ClinicalAlfasigma Spa
Parkinson Disease
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CKD-512CKD-512Phase 1 ClinicalChong Kun Dang Pharmaceutical Corp
Neoplasms; Solid tumours
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JNJ-86974680JNJ-86974680Phase 1 ClinicalJohnson & Johnson Enterprise Innovation Inc
Carcinoma, Non-Small-Cell Lung; Prostatic Neoplasms
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YZJ-5053YZJ5053; YZJ-5053Phase 1 ClinicalShanghai Haiyan Pharmaceutical Technology Co Ltd
Neoplasm Metastasis; Solid tumours
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CT-1500CT-1500Phase 1 ClinicalCircadian Technologies Ltd
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DZD-2269DZD-2269Phase 1 ClinicalDizal Pharmaceutical Co Ltd
Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant
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INCB-106385INCB-106385Phase 1 ClinicalIncyte Corp
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Gastrointestinal Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms
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CS-3005CS-3005Phase 1 ClinicalCstone Pharmaceuticals (Suzhou) Co Ltd
Solid tumours
詳細

市販薬剤に関する情報

英語名研究コード研究開発ステージ会社オリジナル製品名最初に承認をした国最初の適応症最初に承認を受けた会社承認された日付適応症臨床試験
Regadenoson HydrateCVT-3146ApprovedAstellas Pharma IncRapiscan, 海诺生, LexiscanUnited StatesContrast agentsAstellas Pharma Inc2008-04-10
Anemia, Sickle Cell; Astrocytoma; Cardiovascular contrast agents; Cardiovascular Diseases; Contrast agents; Coronary Artery Disease; Coronavirus Disease 2019 (COVID-19); Diagnostic agents; Glioblastoma; Glioma; Heart Diseases; Myocardial Ischemia; Oligodendroglioma; Pneumonia; Rejection of lung transplantation; Retinal Artery Occlusion
詳細
Caffeine/Ergotamine TartrateApprovedNovartis Pharma AgCafergotJapanVascular Headaches; Migraine Disorders; Tension-Type HeadacheNichi-Iko Pharmaceutical Co Ltd1948-11-26
Migraine Disorders; Tension-Type Headache; Vascular Headaches
詳細
OxtriphyllineApprovedTheocolinCanadanull
Asthma
詳細
Caffeine/Metamizole Sodium/Dihydroergotamine MesylateApprovedCefaliv
Migraine Disorders
詳細
AdenineApprovedLeuconJapanLeukopeniaOhara Pharmaceutical Co Ltd
Leukemia; Leukopenia
詳細
Acetaminophen/Butalbital/Caffeine/Codeine PhosphateApprovedActavis Laboratories Ut IncUnited StatesHeadache; Headache DisordersActavis Laboratories Ut Inc1992-07-30
Headache; Headache Disorders
詳細
IstradefyllineKW-6002ApprovedKyowa Hakko Kirin Co LtdNourianz, NouriastJapanParkinson DiseaseKyowa Hakko Kirin Co Ltd2013-03-25
Amyotrophic Lateral Sclerosis; Cognition Disorders; Hepatic Insufficiency; Movement Disorders; Parkinson Disease; Restless Legs Syndrome; Sleep Wake Disorders; Substance-Related Disorders
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Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine/Mannitol/Sodium ChlorideApproved
詳細
Sodium Citrate/Citric Acid/DextroseApproved
詳細
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/AdenineApproved
詳細
Aspirin/Acetaminophen/Caffeine/ThiamineApproved
Fever; Pain
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Propranolol hydrochloride/Caffeine/Phenytoin SodiumApprovedMainland ChinaHebei Tiancheng Pharmaceutical Co Ltd
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Salicylamide/Acetaminophen/CaffeineApproved
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Compound Paracetamol Caffeine and Pseudoephedrine HydrochlorideApproved
Common Cold
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Acetaminophen/Methylephedrine Hydrochloride/Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Caffeine/SulfogaiacolApprovedMainland ChinaCommon ColdZhejiang Apeloa Kangyu Pharmaceutical Co Ltd
Common Cold
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Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Sodium Citrate/Ammonium Chloride/CaffeineApproved尔可芬
Cough
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Acetaminophen/Caffeine/Codeine Phosphate/Diphenhydramine HydrochlorideApproved斯力帮
Headache
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Ferric Ammonium Citrate/Vitamin B1/Sodium glycerophosphate/CaffeineApproved
Ischemia
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Norethidranum Dipropionas/Caffeine/Vitamin B6ApprovedMainland ChinaContraceptionHuazhong Pharmaceutical Co Ltd1981-01-01
Contraception
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Acetaminophen/Propyphenazone/CaffeineApproved散利痛, 散列通
Common Cold
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Quinine Hydrochloride Hydrate/CaffeineApproved
Malaria
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Dihydroergocryptine/CaffeineApproved洛斯宝, VASOBRAL
Diabetes Mellitus; Diabetic Retinopathy
詳細
Aminophenazone/Phenacetin/CaffeineApproved
Fever; Pain
詳細
Aminophenazone/Caffeine/Calcium GlycerophosphateApproved
Dysmenorrhea; Headache; Neuralgia
詳細
Acetaminophen/Caffeine/Chlorphenamine MaleateApproved
Common Cold
詳細
Aminophenazone/Caffeine/Chlorphenamine MaleateApproved
Common Cold; Headache; Neuralgia
詳細
Aspirin/Caffeine/Codeine PhosphateApproved柯克
Pain
詳細
Acetaminophen/Pseudoephedrine Hydrochloride/CaffeineApproved
Common Cold
詳細
Aspirin/Acetaminophen/Caffeine/Chlorphenamine MaleateApproved
Common Cold
詳細
Aspirin/Caffeine/Chlorphenamine Maleate/Tartaric AcidApproved
Common Cold
詳細
Acetaminophen/Caffeine/Pseudoephedrine Hydrochloride/Chlorphenamine MaleateApproved
Common Cold
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Aminophenazone/Phenacetin/Caffeine/PhenobarbitalApproved
Migraine Disorders
詳細
Acetaminophen/Chlorphenamine Maleate/Caffeine/GuaifenesinApproved
Common Cold
詳細
Acetaminophen/Amantadine Hydrochloride/Caffeine/Artificial BezoarApproved
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詳細
Acetaminophen/Salicylamide/Pseudoephedrine Hydrochloride/Caffeine/Triprolidine Hydrochloride HydrateApproved联邦菲迪乐
Common Cold
詳細
Sodium Benzoate/CaffeineApproved
Central Nervous System Diseases
詳細
Aminophenazone/CaffeineApproved
Fever
詳細
Antipyrine/CaffeineApproved
Common Cold
詳細
Aspirin/CaffeineApproved
Common Cold
詳細
Antipyrine/Caffeine/Citric AcidApproved米格来宁Mainland ChinaSedationMudanjiang Lingtai Medicdment Co Ltd, Xi'An Disai Biological Pharmaceutical Co Ltd, Heilongjiang Hasing Pharmaceutical Group Co Ltd, Huadong Medicine (Xi'An) Bodyguard Pharmaceutical Co Ltd1982-01-01
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詳細
Aminophenazone/Acetaminophen/Caffeine/Chlorphenamine MaleateApproved克感敏, 扑感敏, 朴感敏
Common Cold
詳細
Acetaminophen/Caffeine/Ephedrine Hydrochloride/Diphenhydramine HydrochlorideApproved
Influenza, Human
詳細
Acetaminophen/Caffeine/Chlorphenamine Maleate/Artificial BezoarApproved
Common Cold
詳細
Aspirin/Phenacetin/CaffeineApproved
Arthralgia; Dysmenorrhea; Fever; Headache; Neuralgia; Toothache
詳細
Aspirin/Caffeine/AcetaminophenApprovedUnited StatesMigraine DisordersHaleon PLC
Anesthesia; Migraine Disorders
詳細
Acetaminophen/Butalbital/CaffeineApproved
Headache
詳細
Acetaminophen/CaffeineApprovedZentiva AsMainland ChinaPainSino--American Shanghai Squibb Pharmaceutical Ltd
Pain
詳細
Sodium glycerophosphate/Caffeine/Vitamin B/Phosphoric Acid/NiacinApproved
詳細
Acetaminophen/Caffeine/Phenylephrine Hydrochloride/Chlorphenamine Maleate/Vitamin BApproved
詳細
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Common Cold
詳細
Brompheniramine Maleate/Bromhexine Hydrochloride/Caffeine/Acetaminophen/Phenylephrine HydrochlorideApproved
Common Cold
詳細
Acetaminophen/Amantadine Hydrochloride/Caffeine/Chlorphenamine Maleate/Artificial BezoarApproved复方氨酚烷胺Mainland ChinaCommon Coldnull1984-01-01
Common Cold
詳細
CaffeineApproved
Apnea; Cocaine-Related Disorders; Cognitive Dysfunction; Consciousness; Delirium; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disorders of Excessive Somnolence; Fatigue; Fetal Membranes, Premature Rupture; Intermittent Claudication; Memory Disorders; Mental Fatigue; Parkinson Disease; Postoperative Cognitive Complications; Sexual Dysfunction, Physiological; Sleepiness; Spinal Cord Injuries
詳細