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ADAM17

ADAM17信息

英文名称:Disintegrin and metalloproteinase domain-containing protein 17上市药物数量0
中文名称去整合素和金属蛋白酶-17临床药物数量2
靶点别称EC:3.4.24.86，ADAM17 Protein，ADAM 17，Snake venom-like protease，CSVP，CD156b，ADAM17，ADAM Metallopeptidase Domain 17，TNF-Alpha Convertase，TACE，TNF-Alpha Converting Enzyme，TNF-Alpha-Converting Enzyme，CD156b Antigen，EC 3.4.24.86，NISBD1，NISBD，Disintegrin and metalloproteinase domain-containing protein 17，Tumor Necrosis Factor， Alpha， Converting Enzyme，ADAM Metallopeptidase Domain 18，ADAM18最高研发阶段Phase 1 Clinical
英文名称:Disintegrin and metalloproteinase domain-containing protein 17
中文名称去整合素和金属蛋白酶-17
靶点别称EC:3.4.24.86，ADAM17 Protein，ADAM 17，Snake venom-like protease，CSVP，CD156b，ADAM17，ADAM Metallopeptidase Domain 17，TNF-Alpha Convertase，TACE，TNF-Alpha Converting Enzyme，TNF-Alpha-Converting Enzyme，CD156b Antigen，EC 3.4.24.86，NISBD1，NISBD，Disintegrin and metalloproteinase domain-containing protein 17，Tumor Necrosis Factor， Alpha， Converting Enzyme，ADAM Metallopeptidase Domain 18，ADAM18
上市药物数量0
临床药物数量2
最高研发阶段Phase 1 Clinical

ADAM17产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Mouse (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

ADAM17分子背景

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.

ADAM17分子别名

ADAM17,TACE,CD156b
  • 分子信息
  • 产品列表