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4-1BB

4-1BB

4-1BB 詳細

Molecule Name
Tumor necrosis factor receptor superfamily member 9
分子の別称
TNFRSF9,4-1BB,CD137,CDw137,ILA
Drug Development Progress
治験薬の数78
市販薬剤の数0
研究＆開発段階Phase 3 Clinical
ターゲットの別称
TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB
バックグランド
4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

4-1BB 製品リスト

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  • 유***진2026-04-21
    Human 4-1BB / TNFRSF9 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
    I purchased ACRO’s Human 4-1BB (His Tag) for our recent binding affinity studies. The most impressive aspect was the provided MALS (Multi-Angle Light Scattering) data, which gave us high confidence in the protein's oligomeric state and purity before even starting our experiments. Since 4-1BB function is highly dependent on its structural integrity, having MALS-verified molecular weight data is a huge advantage. We observed excellent consistency in our SPR (Surface Plasmon Resonance) assays with minimal lot-to-lot variation. Highly recommended for researchers requiring high-precision analytical data.
  • M***i2023-03-21
    Human 4-1BB / TNFRSF9 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
    I have ordered this material several times for use in Biacore/SPR assays. I have been able to obtain consistent, high-quality results with different lots of this antigen and was able to reproduce kinetic measurements reported in literature for commercial anti-4-1BB molecules. Because 4-1BB is glycosylated, the molecular weight reported by SEC-MALS is helpful for estimating Rmax for my experiments. We have also used this antigen to successfully capture anti-4-1BB out of serum in ELISAs.