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Cynomolgus TSLP (R127A, R130S) Protein, His Tag (HPLC verified)

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  • 分子别名（Synonym）

    TSLP

  • 表达区间及表达系统（Source）

    Cynomolgus TSLP (R127A, R130S) Protein, His Tag (TSP-C52H4) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 - Gln 159 (Accession # A0A7N9CAT7-1 (R127A, R130S)).

    Predicted N-terminus: Tyr 29

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    TSLP Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 16.9 kDa. The protein migrates as 21-30 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

    90% as determined by SEC-HPLC.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    TSLP SDS-PAGE

    Cynomolgus TSLP (R127A, R130S) Protein, His Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    TSLP SEC-HPLC

    The purity of Cynomolgus TSLP (R127A, R130S) Protein, His Tag (Cat. No. TSP-C52H4) was greater than 90% as determined by SEC-HPLC.

  • 活性（Bioactivity）-ELISA

    TSLP ELISA

    Immobilized Human TSLP R, Fc Tag (Cat. No. TSR-H525a) at 5 μg/mL (100 μL/well) can bind Cynomolgus TSLP (R127A, R130S), His Tag (Cat. No. TSP-C52H4) with a linear range of 1-4 ng/mL (QC tested).

    Protocol

  • TSLP ELISA

    Immobilized Cynomolgus TSLP (R127A, R130S), His Tag (Cat. No. TSP-C52H4) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human TSLP Antibody, Human IgG2 with a linear range of 0.5-8 ng/mL (Routinely tested).

    Protocol

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背景介绍

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

前沿进展

 
药物研发进展
  • 英文全称：

    Thymic stromal lymphopoietin

  • 中文全称：

    胸腺基质淋巴细胞生成素

  • 种类：

  • 上市药物数量：

    1 详情

  • 临床药物数量：

    23 详情

  • 最高研发阶段：

    批准上市

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