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Cynomolgus MMP-9 Protein, His Tag (active enzyme)

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  • 分子别名（Synonym）

    MMP9,CLG4B,GELB,MANDP2,Gelatinase B

  • 表达区间及表达系统（Source）

    Cynomolgus MMP-9 Protein, His Tag (MM9-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 469 (Accession # XP_005569271.2). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.

    Predicted N-terminus: Ala 20

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    MMP-9 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 51.8 kDa. The protein migrates as 65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in 25 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    MMP-9 SDS-PAGE

    Cynomolgus MMP-9 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性（Bioactivity）

    Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >1500 pmol/min/μg (QC tested).

    Protocol

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背景介绍

Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

前沿进展

 
药物研发进展
  • 英文全称：

    Matrix metalloproteinase 9

  • 中文全称：

    基质金属蛋白酶-9

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    3 详情

  • 最高研发阶段：

    临床三期

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