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Human Cadherin-6 / KCAD / CDH6 Protein, His Tag

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  • 分子别名(Synonym)

    CDH6,CAD6,KCAD,K-cadherin,Cadherin-6

  • 表达区间及表达系统(Source)

    Human Cadherin-6, His Tag (CA6-H5229) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Ala 615 (Accession # AAH00019).

    Predicted N-terminus: Thr 19 & Ser 54

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Cadherin-6 Structure

    This protein carries a polyhistidine tag at the C-terminus. The Human Cadherin-6 will be further processed into mature form (Ser 54-Ala 615). The protein has a calculated MW of 67.2 kDa (pro-form) and 63.4 kDa (mature-form). The protein migrates as 86-96 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >85% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    Cadherin-6 SDS-PAGE

    Human Cadherin-6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%undefined.

  • 活性(Bioactivity)-ELISA

     Cadherin-6 ELISA

    Immobilized Human Cadherin-6, His Tag (Cat. No. CA6-H5229) at 1 μg/mL (100 μL/well) can bind Human Cadherin-6 Antibody, Mouse IgG1 with a linear range of 0.1-1 ng/mL (QC tested).

    Protocol
  •  Cadherin-6 ELISA

    Immobilized Human Cadherin-6, His Tag (Cat. No. CA6-H5229) at 1 μg/mL (100 μL/well) can bind Raludotatug with a linear range of 0.02-1 ng/mL (Routinely tested).

    Protocol

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背景介绍

Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.

前沿进展

 
药物研发进展
  • 英文全称:

    Cadherin-6

  • 中文全称:

    钙粘蛋白6

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    3 详情

  • 最高研发阶段:

    临床三期

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