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Human ADAM9 Protein, His Tag (206 - 413) (active enzyme)

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  • 分子别名（Synonym）

    Disintegrin and metalloproteinase domain-containing protein 9 (EC:3.4.24.-) Cellular disintegrin-related protein,Meltrin-gamma,Metalloprotease,disintegrin,cysteine-rich protein 9,Myeloma cell metalloproteinase,ADAM9,KIAA0021, MCMP, MDC9, MLTNG

  • 表达区间及表达系统（Source）

    Human ADAM9 Protein, His Tag (206 - 413) (AD9-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ala 206 - Ser 413 (Accession # Q13443-1).

    Predicted N-terminus: Ala 206

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    ADAM9 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 24.6 kDa. The protein migrates as 25-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in 20 mM Tris, 800 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    ADAM9 SDS-PAGE

    Human ADAM9 Protein, His Tag (206 - 413) on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性（Bioactivity）-SPR

    ADAM9 SPR

    Anti-ADAM9 Antibody captured on Protein A Chip can bind Human ADAM9 Protein, His Tag (206 - 413) (Cat. No. AD9-H52H4) with an affinity constant of 58.0 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

  • 活性（Bioactivity）

    Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2. The specific activity is >40 pmol/min/µg (QC tested).

    Protocol

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背景介绍

ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developmental process, inflammation, and degenerative diseases.Recently, increasing evidence has shown that ADAM9 plays an important role in tumor biology. Overexpression of ADAM9 has been found in several cancer types and is correlated with tumoraggressiveness and poor prognosis. In addition, through either proteolytic or non-proteolytic pathways, ADAM9 promotes tumor progression, therapeutic resistance, and metastasis of cancers.Therefore, comprehensively understanding the mechanism of ADAM9 is crucial for the development of therapeutic anti-cancer strategies. In this review, we summarize the current understanding of ADAM9 in biological function, pathophysiological diseases, and various cancers. Recent advances in therapeutic strategies using ADAM9-related pathways are presented as well.

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  • 英文全称：

    Disintegrin and metalloproteinase domain-containing protein 9

  • 中文全称：

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    0 详情

  • 临床药物数量：

    2 详情

  • 最高研发阶段：

    临床二期

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