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Human Activin RIIB / ACVR2B Protein, His Tag (MALS & SPR verified)

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  • 分子别名（Synonym）

    ACVR2B,ACTRIIB,MGC116908

  • 表达区间及表达系统（Source）

    Human Activin RIIB, His Tag (ACB-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Thr 137 (Accession # Q13705-1).

    Predicted N-terminus: Ser 19

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Activin RIIB Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 20-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

数据展示

  • 电泳（SDS-PAGE）

    Activin RIIB SDS-PAGE

    Human Activin RIIB, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Activin RIIB SEC-MALS

    The purity of Human Activin RIIB, His Tag (Cat. No. ACB-H5226) is more than 90% and the molecular weight of this protein is around 18-25 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-SPR

    Activin RIIB SPR

    Human Activin RIIB, His Tag (Cat. No. ACB-H5226) immobilized on CM5 Chip can bind Human Activin A, premium grade (Cat. No. ACA-H421b) with an affinity constant of 0.164 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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背景介绍

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

前沿进展

 
药物研发进展
  • 英文全称：

    Activin receptor type-2B

  • 中文全称：

    激活素受体-2B

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    3 详情

  • 最高研发阶段：

    临床二期

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