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Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11)

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  • 抗体来源（Source）

    Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.

  • 克隆号（Clone）

    1M1G11

  • 种属（Species）

    Rabbit

  • 亚型（Isotype）

    Rabbit IgG | Rabbit Kappa

  • 偶联（Conjugate）

    Biotin

  • 抗体类型（Antibody Type）

    Recombinant Monoclonal

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with Eribulin.

  • 应用（Application）

    Application
    Recommended Usage
    ELISA
    0.1-125 ng/mL

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

  • 纯化（Purification）

    Protein A purified / Protein G purified

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 电泳（SDS-PAGE）

    Eribulin SDS-PAGE

    Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性（Bioactivity）-ELISA

    Eribulin ELISA

    Immobilized Human FOLR1, Fc Tag (Cat. No. FO1-H5253) at 1 μg/mL, add Farletuzumab Ecteribulin and then add Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-BMY12b) at 0.05 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

    Protocol

  • Eribulin ELISA

    Immobilized Human FOLR1, Fc Tag (Cat. No. FO1-H5253) at 1 μg/mL, add Farletuzumab Ecteribulin in the 100% Human Serum and then add Biotinylated Rabbit Anti-Eribulin Antibody, Rabbit IgG (1M1G11) (Cat. No. ERN-BMY12b) at 0.05 μg/mL (QC tested).

    Protocol

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背景介绍

Eribulin is a synthetic analogue of the macrocyclic polyether halichondrin B, which was originally isolated from the Asian sea sponge Halichondria okadai. Eribulin binds specifically to the β-tubulin subunit on the (+) end of the microtubule and potently inhibits elongation of the formed microtubule, while having little or no effect on microtubule depolymerization. Eribulin's potent antimitotic activity and nonmitotic effects on tumor biology make it an interesting candidate for investigation as a MTA payload for ADCs.

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