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APC-CY7-Labeled Monoclonal Anti-Human CD8 Antibody, Mouse IgG

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产品详情

  • 应用（Application）

    Flow Cytometry (Evaluation of the expression of CD8 on Human cells).

  • 种属（Species）

    Mouse

  • 亚型（Isotype）

    Mouse IgG

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with CD8 protein.

  • 种属反应性（Reactivity）

    Human

  • 偶联（Conjugate）

    APC-CY7

    Excitation Wavelength: 637 nm

    Emission Wavelength: 780 nm

  • 推荐稀释比（Recommended Dilution）

    1:20

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, 0.2% BSA, 0.03% Proclin 300, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 存储（Storage）

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 活性（Bioactivity）-FACS

    CD8 FACS

    Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with APC-CY7-Labeled Monoclonal Anti-Human CD8 Antibody Mouse IgG1 (Cat. No. FABm003-05) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 2.5e5 cells in a final volume of 100 µL), compared with isotype control antibody. APC-CY7 signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

前沿进展

 
药物研发进展
  • 英文全称：

    Cluster of differentiation 8

  • 中文全称：

    分化群8

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    15 详情

  • 最高研发阶段：

    临床三期

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