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FITC-Labeled Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3)

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  • 抗体来源（Source）

    Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3) is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

  • 应用（Application）

    Flow Cytometry (Detection the expression of CD3 on Human cells).

  • 克隆号（Clone）

    OKT3

  • 种属（Species）

    Mouse

  • 亚型（Isotype）

    Mouse IgG2a | Mouse Kappa

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with CD3 protein.

  • 种属反应性（Reactivity）

    Human

  • 免疫原（Immunogen）

    Purified Human CD3ε Protein.

  • 偶联（Conjugate）

    FITC

    Excitation source: 488 nm spectral line, argon-ion laser

    Excitation Wavelength: 488 nm

    Emission Wavelength: 535 nm

  • 同型对照（Isotype Control）

    The Isotype control is sold separately and you can search for Cat. No. DNP-FM487 for product information.

  • 推荐稀释比（Recommended Dilution）

    1:20

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 存储（Storage）

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 活性（Bioactivity）-FACS

    CD3 FACS

    Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with FITC-Labeled Monoclonal Anti-Human CD3 Antibody Mouse IgG2a (Cat. No. FABm001-03) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 2.5e5 cells in a final volume of 100 µL), compared with isotype control antibody. FITC signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

前沿进展

 
药物研发进展
  • 英文全称：

    T cell surface glycoprotein CD3

  • 中文全称：

    T细胞表面糖蛋白CD3复合体

  • 种类：

  • 上市药物数量：

    8 详情

  • 临床药物数量：

    177 详情

  • 最高研发阶段：

    临床二期

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