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CTLA-4

CTLA-4信息

英文名称:Cytotoxic T-Lymphocyte-Associated Antigen 4上市药物数量4
中文名称细胞毒性T淋巴细胞相关抗原4临床药物数量63
靶点别称Celiac Disease 3，Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4，Cytotoxic T-Lymphocyte Protein 4，CD152，Cytotoxic T-lymphocyte-associated antigen 4，CTLA4，CTLA-4，Cytotoxic T-Lymphocyte Associated Protein 4，Insulin-Dependent Diabetes Mellitus 12，Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form，Cytotoxic T-Lymphocyte-Associated Serine Esterase-4，CD152 Isoform，CD152 Antigen，CELIAC3，IDDM12，ALPS5，GRD4，GSE，CD，CTLA-4 Antigen最高研发阶段Phase 2 Clinical
英文名称:Cytotoxic T-Lymphocyte-Associated Antigen 4
中文名称细胞毒性T淋巴细胞相关抗原4
靶点别称Celiac Disease 3，Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4，Cytotoxic T-Lymphocyte Protein 4，CD152，Cytotoxic T-lymphocyte-associated antigen 4，CTLA4，CTLA-4，Cytotoxic T-Lymphocyte Associated Protein 4，Insulin-Dependent Diabetes Mellitus 12，Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form，Cytotoxic T-Lymphocyte-Associated Serine Esterase-4，CD152 Isoform，CD152 Antigen，CELIAC3，IDDM12，ALPS5，GRD4，GSE，CD，CTLA-4 Antigen
上市药物数量4
临床药物数量63
最高研发阶段Phase 2 Clinical

CTLA-4产品列表

  • 属性

    Protein (21)Kits (3)

  • 产品库

    在线 (24)

  • 物种

    Cynomolgus / Rhesus macaque (4)Human (12)Mouse (4)Rabbit (2)Rat (2)

  • 标签

    His Tag & Avi Tag (4)Fc Tag & Avi Tag (3)His Tag (7)Fc Tag (5)Mouse IgG Fc Tag (1)Strep Tag (1)- (3)

  • 标记

    Biotin-labeled (7)Unconjugated (13) (3)PE Labeled (1)

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CTLA-4分子背景

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

CTLA-4分子别名

CTLA4,CD152

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