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Claudin-18.1

Claudin-18.1信息

英文名称:Claudin-18 splice variant 2上市药物数量1
中文名称密蛋白-18剪接变体2临床药物数量74
靶点别称UNQ778/PRO1572，CLDN18，Claudin 18，Surfactant Associated Protein J，Surfactant， Pulmonary Associated Protein J，Surfactant Associated 5，Claudin-18，SFTA5，SFTPJ，Claudin 18.2，CLDN18.2最高研发阶段Phase 3 Clinical
英文名称:Claudin-18 splice variant 2
中文名称密蛋白-18剪接变体2
靶点别称UNQ778/PRO1572，CLDN18，Claudin 18，Surfactant Associated Protein J，Surfactant， Pulmonary Associated Protein J，Surfactant Associated 5，Claudin-18，SFTA5，SFTPJ，Claudin 18.2，CLDN18.2
上市药物数量1
临床药物数量74
最高研发阶段Phase 3 Clinical

Claudin-18.1产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (1)在研 (1)

  • 物种

    Human (2)

  • 标签

    His Tag & Strep Tag (1)- (1)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

Claudin-18.1分子背景

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

Claudin-18.1分子别名

Claudin-18.1,CLDN18,Claudin-18
  • 分子信息
  • 产品列表